Yoon. Jeon, et.al., TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells., The Journal of biological chemistry, 2011, 286

http://rdf.ncbi.nlm.nih.gov/pubmed/21149450

Yoon. Jeon, et.al., TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells., The Journal of biological chemistry, 2011, 286

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Topbp1<tm1.1Dsh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4947431
• Topbp1<tm1.2Dsh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4947432

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased cell proliferation_Topbp1<tm1.2Dsh>/Topbp1<tm1.2Dsh>
  http://metadb.riken.jp/0000352I129P2OlaHsd129S4SvJaeSorC57BL6C57BL6JTopbp1tm12DshTopbp1tm12DshTopbp1tm12Dsh
• embryonic growth arrest_Topbp1<tm1.2Dsh>/Topbp1<tm1.2Dsh>
  http://metadb.riken.jp/0001730I129P2OlaHsd129S4SvJaeSorC57BL6C57BL6JTopbp1tm12DshTopbp1tm12DshTopbp1tm12Dsh
• no abnormal phenotype detected_Topbp1<tm1.1Dsh>/Topbp1<tm1.1Dsh>
  http://metadb.riken.jp/0002169I129P2OlaHsd129S4SvJaeSorC57BL6Topbp1tm11DshTopbp1tm11DshTopbp1tm11Dsh
• abnormal cell cycle_Topbp1<tm1.1Dsh>/Topbp1<tm1.1Dsh>
  http://metadb.riken.jp/0003077I129P2OlaHsd129S4SvJaeSorC57BL6Topbp1tm11DshTopbp1tm11DshTopbp1tm11Dsh
• abnormal cell physiology_Topbp1<tm1.1Dsh>/Topbp1<tm1.1Dsh>
  http://metadb.riken.jp/0005621I129P2OlaHsd129S4SvJaeSorC57BL6Topbp1tm11DshTopbp1tm11DshTopbp1tm11Dsh
• embryonic lethality at implantation, complete penetrance_Topbp1<tm1.2Dsh>/Topbp1<tm1.2Dsh>
  http://metadb.riken.jp/0011093I129P2OlaHsd129S4SvJaeSorC57BL6C57BL6JTopbp1tm12DshTopbp1tm12DshTopbp1tm12Dsh
他1件を見る
• increased embryonic tissue cell apoptosis_Topbp1<tm1.2Dsh>/Topbp1<tm1.2Dsh>
  http://metadb.riken.jp/0013504I129P2OlaHsd129S4SvJaeSorC57BL6C57BL6JTopbp1tm12DshTopbp1tm12DshTopbp1tm12Dsh

class

http://purl.org/net/cito/citesAsAuthority

• Topbp1<tm1.1Dsh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4947431
• Topbp1<tm1.2Dsh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4947432