absent Paneth cells_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>

http://metadb.riken.jp/0014076I129P2OlaHsd129X1SvJC57BL6Cdc42tm1BrakCdc42tm1BrakGtROSA26Sortm1EYFPCosGtROSA26SorLgr5tm1creERT2CleLgr5Cdc42tm1BrakLgr5tm1creERT2CleGtROSA26SorLgr5GtROSA26Sortm1EYFPCos

absent Paneth cells_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cell division cycle 42
  http://metadb.riken.jp/db/mgi_rdf/MGI:106211
• leucine rich repeat containing G protein coupled receptor 5
  http://metadb.riken.jp/db/mgi_rdf/MGI:1341817
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdc42<tm1Brak>/Cdc42<tm1Brak>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdc42<tm1Brak>|Lgr5<tm1(cre/ERT2)Cle>|Gt(ROSA)26Sor<+>|Lgr5<+>|Gt(ROSA)26Sor<tm1(EYFP)Cos>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• http://purl.obolibrary.org/obo/MP_0014076

文献

http://purl.org/net/cito/citesAsAuthority

• Ryotaro. Sakamori, et.al., Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice., The Journal of clinical investigation, 2012, 122
  http://rdf.ncbi.nlm.nih.gov/pubmed/22354172