Ryotaro. Sakamori, et.al., Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice., The Journal of clinical investigation, 2012, 122

http://rdf.ncbi.nlm.nih.gov/pubmed/22354172

Ryotaro. Sakamori, et.al., Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice., The Journal of clinical investigation, 2012, 122

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal enterocyte morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0000479IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• abnormal intestinal goblet cell morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0003449IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• abnormal intestinal enteroendocrine cell morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0010802IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• postnatal growth retardation_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0001732IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• increased small intestinal crypt cell apoptosis_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>
  http://metadb.riken.jp/0008800I129P2OlaHsd129X1SvJC57BL6Cdc42tm1BrakCdc42tm1BrakGtROSA26Sortm1EYFPCosGtROSA26SorLgr5tm1creERT2CleLgr5Cdc42tm1BrakLgr5tm1creERT2CleGtROSA26SorLgr5GtROSA26Sortm1EYFPCos
• abnormal small intestinal crypt cell physiology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0010156IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• intestinal edema_Cdc42<tm1Brak>/Cdc42<+>,Rab8a<tm1.1Aha>/Rab8a<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0003288IC57BL6JSJLCdc42tm1BrakCdc42Rab8atm11AhaRab8aTgVil1cre997Gum0Rab8atm11AhaCdc42tm1BrakRab8aCdc42TgVil1cre997Gum
• abnormal intestinal epithelium morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>
  http://metadb.riken.jp/0000488I129P2OlaHsd129X1SvJC57BL6Cdc42tm1BrakCdc42tm1BrakGtROSA26Sortm1EYFPCosGtROSA26SorLgr5tm1creERT2CleLgr5Cdc42tm1BrakLgr5tm1creERT2CleGtROSA26SorLgr5GtROSA26Sortm1EYFPCos
• abnormal intestine physiology_Cdc42<tm1Brak>/Cdc42<+>,Rab8a<tm1.1Aha>/Rab8a<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0010155IC57BL6JSJLCdc42tm1BrakCdc42Rab8atm11AhaRab8aTgVil1cre997Gum0Rab8atm11AhaCdc42tm1BrakRab8aCdc42TgVil1cre997Gum
• abnormal intestine physiology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0010155IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• abnormal intestinal epithelium morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0000488IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• intestinal edema_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0003288IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• absent Paneth cells_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>
  http://metadb.riken.jp/0014076I129P2OlaHsdC57BL6Cdc42tm1BrakCdc42tm1BrakLgr5tm1creERT2CleLgr5Cdc42tm1BrakLgr5Lgr5tm1creERT2Cle
• abnormal anus morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0005034IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• increased small intestinal crypt cell apoptosis_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0008800IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• abnormal intestine morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0000477IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• abnormal defecation_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0003866IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• abnormal Paneth cell morphology_Cdc42<tm1Brak>/Cdc42<+>,Rab8a<tm1.1Aha>/Rab8a<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0004843IC57BL6JSJLCdc42tm1BrakCdc42Rab8atm11AhaRab8aTgVil1cre997Gum0Rab8atm11AhaCdc42tm1BrakRab8aCdc42TgVil1cre997Gum
• abnormal crypts of Lieberkuhn morphology_Cdc42<tm1Brak>/Cdc42<+>,Rab8a<tm1.1Aha>/Rab8a<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0000490IC57BL6JSJLCdc42tm1BrakCdc42Rab8atm11AhaRab8aTgVil1cre997Gum0Rab8atm11AhaCdc42tm1BrakRab8aCdc42TgVil1cre997Gum
• abnormal small intestinal villus morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>
  http://metadb.riken.jp/0008108I129P2OlaHsd129X1SvJC57BL6Cdc42tm1BrakCdc42tm1BrakGtROSA26Sortm1EYFPCosGtROSA26SorLgr5tm1creERT2CleLgr5Cdc42tm1BrakLgr5tm1creERT2CleGtROSA26SorLgr5GtROSA26Sortm1EYFPCos
• abnormal crypts of Lieberkuhn morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>
  http://metadb.riken.jp/0000490I129P2OlaHsd129X1SvJC57BL6Cdc42tm1BrakCdc42tm1BrakGtROSA26Sortm1EYFPCosGtROSA26SorLgr5tm1creERT2CleLgr5Cdc42tm1BrakLgr5tm1creERT2CleGtROSA26SorLgr5GtROSA26Sortm1EYFPCos
• premature death_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0002083IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• abnormal cellular glucose import_Cdc42<tm1Brak>/Cdc42<+>,Rab8a<tm1.1Aha>/Rab8a<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0003925IC57BL6JSJLCdc42tm1BrakCdc42Rab8atm11AhaRab8aTgVil1cre997Gum0Rab8atm11AhaCdc42tm1BrakRab8aCdc42TgVil1cre997Gum
• decreased body size_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0001265IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• abnormal crypts of Lieberkuhn morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0000490IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• absent Paneth cells_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>
  http://metadb.riken.jp/0014076I129P2OlaHsd129X1SvJC57BL6Cdc42tm1BrakCdc42tm1BrakGtROSA26Sortm1EYFPCosGtROSA26SorLgr5tm1creERT2CleLgr5Cdc42tm1BrakLgr5tm1creERT2CleGtROSA26SorLgr5GtROSA26Sortm1EYFPCos
• decreased Paneth cell number_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0013486IC57BL6JSJLCdc42tm1BrakCdc42tm1BrakTgVil1cre997Gum0TgVil1cre997GumCdc42tm1Brak
• abnormal crypts of Lieberkuhn morphology_Cdc42<tm1Brak>/Cdc42<tm1Brak>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>
  http://metadb.riken.jp/0000490I129P2OlaHsdC57BL6Cdc42tm1BrakCdc42tm1BrakLgr5tm1creERT2CleLgr5Cdc42tm1BrakLgr5Lgr5tm1creERT2Cle