increased bone ossification_Acvr1<tm2.1Vlcg>/Acvr1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(tetO-cre)1Jaw/0

http://metadb.riken.jp/0020039I129129S4SvJaeC57BL6C57BL6NTacAcvr1tm21VlcgAcvr1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgtetOcre1Jaw0Acvr1GtROSA26Sortm1rtTAM2JaeAcvr1tm21VlcgTgtetOcre1JawGtROSA26Sor

increased bone ossification_Acvr1<tm2.1Vlcg>/Acvr1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(tetO-cre)1Jaw/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• activin A receptor, type 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:87911
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 1, Jeffrey A Whitsett
  http://metadb.riken.jp/db/mgi_rdf/MGI:3028584

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Acvr1<tm2.1Vlcg>/Acvr1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(tetO-cre)1Jaw/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Acvr1<+>|Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>|Acvr1<tm2.1Vlcg>|Tg(tetO-cre)1Jaw|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6NTac

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• http://purl.obolibrary.org/obo/MP_0020039

文献

http://purl.org/net/cito/citesAsAuthority

• Salin A. Chakkalakal, et.al., Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/26896819