Salin A. Chakkalakal, et.al., Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016, 31

http://rdf.ncbi.nlm.nih.gov/pubmed/26896819

Salin A. Chakkalakal, et.al., Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016, 31

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased width of hypertrophic chondrocyte zone_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0003409IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg
• increased bone ossification_Acvr1<tm2.1Vlcg>/Acvr1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0020039I129129S4SvJaeC57BL6C57BL6NTacAcvr1tm21VlcgAcvr1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgtetOcre1Jaw0Acvr1GtROSA26Sortm1rtTAM2JaeAcvr1tm21VlcgTgtetOcre1JawGtROSA26Sor
• abnormal motor capabilities/coordination/movement_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0002066IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg
• abnormal skeleton development_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0002113IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg
• short radius_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0004355IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg
• decreased length of long bones_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0004686IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg
• short humerus_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0004351IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg
• increased bone ossification_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0020039IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg
• abnormal digit morphology_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0002110IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg
• increased chondrocyte proliferation_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0014100IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg
• abnormal motor capabilities/coordination/movement_Acvr1<tm2.1Vlcg>/Acvr1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0002066I129129S4SvJaeC57BL6C57BL6NTacAcvr1tm21VlcgAcvr1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgtetOcre1Jaw0Acvr1GtROSA26Sortm1rtTAM2JaeAcvr1tm21VlcgTgtetOcre1JawGtROSA26Sor
• short tibia_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0002764IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg
• short femur_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0003109IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg
• abnormal long bone epiphyseal plate morphology_Acvr1<tm2.1Vlcg>/Acvr1<+>,Tg(Prrx1-cre)1Cjt/0
  http://metadb.riken.jp/0003055IC57BL6JC57BL6NTacSJLJAcvr1tm21VlcgAcvr1TgPrrx1cre1Cjt0TgPrrx1cre1CjtAcvr1Acvr1tm21Vlcg