L A. Garrett-Sinha, et.al., PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction., Immunity, 1999, 10

http://rdf.ncbi.nlm.nih.gov/pubmed/10229183

L A. Garrett-Sinha, et.al., PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction., Immunity, 1999, 10

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• lethality throughout fetal growth and development, complete penetrance_Spi1<tm1Sing>/Spi1<tm1Sing>,Spib<tm1Mcs>/Spib<tm1Mcs>
  http://metadb.riken.jp/0011099I129SSvEv129X1SvJSpi1tm1SingSpi1tm1SingSpibtm1McsSpibtm1McsSpi1tm1SingSpibtm1Mcs
• decreased B cell proliferation_Spi1<tm1Sing>/Spi1<+>,Spib<tm1Mcs>/Spib<tm1Mcs>
  http://metadb.riken.jp/0005093I129SSvEv129X1SvJSpi1tm1SingSpi1Spibtm1McsSpibtm1McsSpibtm1McsSpi1tm1SingSpi1
• abnormal immature B cell morphology_Spi1<tm1Sing>/Spi1<+>,Spib<tm1Mcs>/Spib<tm1Mcs>
  http://metadb.riken.jp/0005022I129SSvEv129X1SvJSpi1tm1SingSpi1Spibtm1McsSpibtm1McsSpibtm1McsSpi1tm1SingSpi1
• increased B cell apoptosis_Spi1<tm1Sing>/Spi1<+>,Spib<tm1Mcs>/Spib<tm1Mcs>
  http://metadb.riken.jp/0008782I129SSvEv129X1SvJSpi1tm1SingSpi1Spibtm1McsSpibtm1McsSpibtm1McsSpi1tm1SingSpi1
• decreased B cell proliferation_Spib<tm1Mcs>/Spib<tm1Mcs>
  http://metadb.riken.jp/0005093I129S1Sv129X1SvJC57BL6Spibtm1McsSpibtm1McsSpibtm1Mcs
• absent spleen germinal center_Spi1<tm1Sing>/Spi1<+>,Spib<tm1Mcs>/Spib<tm1Mcs>
  http://metadb.riken.jp/0008474I129SSvEv129X1SvJSpi1tm1SingSpi1Spibtm1McsSpibtm1McsSpibtm1McsSpi1tm1SingSpi1
• abnormal immature B cell morphology_Spib<tm1Mcs>/Spib<tm1Mcs>
  http://metadb.riken.jp/0005022I129S1Sv129X1SvJC57BL6Spibtm1McsSpibtm1McsSpibtm1Mcs
• decreased B cell proliferation_Spi1<tm1Sing>/Spi1<+>,Spib<tm1Mcs>/Spib<+>
  http://metadb.riken.jp/0005093I129SSvEv129X1SvJSpi1tm1SingSpi1Spibtm1McsSpibSpi1Spibtm1McsSpi1tm1SingSpib
• abnormal spleen germinal center morphology_Spi1<tm1Sing>/Spi1<+>,Spib<tm1Mcs>/Spib<+>
  http://metadb.riken.jp/0002359I129SSvEv129X1SvJSpi1tm1SingSpi1Spibtm1McsSpibSpi1Spibtm1McsSpi1tm1SingSpib
• abnormal B cell differentiation_Spi1<tm1Sing>/Spi1<+>,Spib<tm1Mcs>/Spib<tm1Mcs>
  http://metadb.riken.jp/0002144I129SSvEv129X1SvJSpi1tm1SingSpi1Spibtm1McsSpibtm1McsSpibtm1McsSpi1tm1SingSpi1
• decreased B cell number_Spi1<tm1Sing>/Spi1<+>,Spib<tm1Mcs>/Spib<tm1Mcs>
  http://metadb.riken.jp/0005017I129SSvEv129X1SvJSpi1tm1SingSpi1Spibtm1McsSpibtm1McsSpibtm1McsSpi1tm1SingSpi1