S G. Rane, et.al., Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia., Nature genetics, 1999, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/10319860

S G. Rane, et.al., Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia., Nature genetics, 1999, 22

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Cdk4<tm1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2154520
• Cdk4<tm1.1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2154521

class

http://purl.org/net/cito/citesAsAuthority

• Cdk4<tm1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2154520
• Cdk4<tm1.1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2154521

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• oligozoospermia_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0002687I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• ketoaciduria_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0002893I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• decreased body size_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001265I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• increased pancreatic beta cell number_Cdk4<tm1.1Bbd>/Cdk4<+>
  http://metadb.riken.jp/0003645I129S1Sv129X1SvJICRCdk4tm11BbdCdk4Cdk4tm11BbdCdk4
• decreased circulating follicle stimulating hormone level_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0002790I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• hyperactivity_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001399I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• impaired limb coordination_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001524I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• decreased circulating progesterone level_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0005185I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• increased pancreatic beta cell number_Cdk4<tm1.1Bbd>/Cdk4<tm1.1Bbd>
  http://metadb.riken.jp/0003645I129S1Sv129X1SvJICRCdk4tm11BbdCdk4tm11BbdCdk4tm11Bbd
• abnormal male reproductive system morphology_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001145I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• polydipsia_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001426I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• abnormal locomotor behavior_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001392I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• abnormal pancreatic islet morphology_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0005215I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• decreased circulating insulin level_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0002727I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• increased body weight_Cdk4<tm1.1Bbd>/Cdk4<tm1.1Bbd>
  http://metadb.riken.jp/0001260I129S1Sv129X1SvJICRCdk4tm11BbdCdk4tm11BbdCdk4tm11Bbd
• increased urine glucose level_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001759I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• Leydig cell hyperplasia_Cdk4<tm1.1Bbd>/Cdk4<tm1.1Bbd>
  http://metadb.riken.jp/0001152I129S1Sv129X1SvJICRCdk4tm11BbdCdk4tm11BbdCdk4tm11Bbd
• female infertility_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001926I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• decreased body weight_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001262I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• small pancreatic islets_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0009172I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• abnormal Sertoli cell morphology_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0002784I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• abnormal female reproductive system morphology_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001119I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• abnormal male reproductive system physiology_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0003698I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• abnormal cell cycle_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0003077I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• small ovary_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001127I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• postnatal lethality_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0002082I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• hyperglycemia_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001559I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• delayed estrous cycle_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0009008I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• abnormal corpus luteum morphology_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0002679I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• polyuria_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001762I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• abnormal female reproductive system physiology_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0003699I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• decreased testis weight_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0004852I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• Leydig cell hypoplasia_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0005536I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• reduced male fertility_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0001922I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd
• abnormal seminiferous tubule morphology_Cdk4<tm1Bbd>/Cdk4<tm1Bbd>
  http://metadb.riken.jp/0002216I129S1Sv129X1SvJICRCdk4tm1BbdCdk4tm1BbdCdk4tm1Bbd