F. Radtke, et.al., Deficient T cell fate specification in mice with an induced inactivation of Notch1., Immunity, 1999, 10

http://rdf.ncbi.nlm.nih.gov/pubmed/10367900

F. Radtke, et.al., Deficient T cell fate specification in mice with an induced inactivation of Notch1., Immunity, 1999, 10

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Notch1<tm2Agt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3043290
• Notch1<tm1Agt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1933835

class

http://purl.org/net/cito/citesAsAuthority

• Notch1<tm2Agt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3043290
• Notch1<tm1Agt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1933835

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• no abnormal phenotype detected_Notch1<tm1Agt>/Notch1<tm1Agt>
  http://metadb.riken.jp/0002169I129Notch1tm1AgtNotch1tm1AgtNotch1tm1Agt
• decreased double-positive T cell number_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005092I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• premature death_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• decreased CD4-positive, alpha beta T cell number_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008075I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• decreased thymocyte number_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000715I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• abnormal thymus cell ratio_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008827I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• decreased single-positive T cell number_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008083I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• small thymus_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000706I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• decreased CD8-positive, alpha-beta T cell number_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008079I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• decreased double-negative T cell number_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005089I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• postnatal growth retardation_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001732I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• abnormal thymus morphology_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000703I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• decreased body weight_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001262I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt
• embryonic lethality during organogenesis, complete penetrance_Notch1<tm2Agt>/Notch1<tm2Agt>
  http://metadb.riken.jp/0011098I129SvC57BL6Notch1tm2AgtNotch1tm2AgtNotch1tm2Agt
• abnormal T cell differentiation_Notch1<tm1Agt>/Notch1<tm1Agt>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002145I129C57BL6CBANotch1tm1AgtNotch1tm1AgtTgMx1cre1Cgn0TgMx1cre1CgnNotch1tm1Agt