M C. Hollander, et.al., Genomic instability in Gadd45a-deficient mice., Nature genetics, 1999, 23

http://rdf.ncbi.nlm.nih.gov/pubmed/10508513

M C. Hollander, et.al., Genomic instability in Gadd45a-deficient mice., Nature genetics, 1999, 23

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gadd45a<tm1Ajf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2182720

class

http://purl.org/net/cito/citesAsAuthority

• Gadd45a<tm1Ajf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2182720

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal chromosome number_Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0004023I129S7SvEvBrdTrp53tm1BrdTrp53tm1BrdTrp53tm1Brd
• increased fibroblast proliferation_Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0011703I129S7SvEvBrdTrp53tm1BrdTrp53tm1BrdTrp53tm1Brd
• abnormal chromosome number_Cdkn1a<tm1Led>/Cdkn1a<tm1Led>
  http://metadb.riken.jp/0004023I129S6SvEvTacCdkn1atm1LedCdkn1atm1LedCdkn1atm1Led
• parturition failure_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0012010EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• abnormal chromosome number_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0004023EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• decreased sensitivity to induced cell death_Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0008944I129S7SvEvBrdTrp53tm1BrdTrp53tm1BrdTrp53tm1Brd
• abnormal mitosis_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0004046EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• increased thymus weight_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0004955EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• abnormal cell physiology_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0005621EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• increased incidence of tumors by ionizing radiation induction_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0004500EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• increased thymocyte number_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0000714EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• increased fibroblast proliferation_Cdkn1a<tm1Led>/Cdkn1a<tm1Led>,Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0011703EI129P2OlaHsd129S6SvEvTacC57BL6orI129S6SvEvTac129X1SvJC57BL6Cdkn1atm1LedCdkn1atm1LedGadd45atm1AjfGadd45atm1AjfCdkn1atm1LedGadd45atm1Ajf
• increased fibroblast proliferation_Cdkn1a<tm1Led>/Cdkn1a<tm1Led>
  http://metadb.riken.jp/0011703I129S6SvEvTacCdkn1atm1LedCdkn1atm1LedCdkn1atm1Led
• abnormal cell physiology_Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0005621I129S7SvEvBrdTrp53tm1BrdTrp53tm1BrdTrp53tm1Brd
• abnormal cell nucleus morphology_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0003111EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• abnormal chromosome number_Cdkn1a<tm1Led>/Cdkn1a<tm1Led>,Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0004023EI129P2OlaHsd129S6SvEvTacC57BL6orI129S6SvEvTac129X1SvJC57BL6Cdkn1atm1LedCdkn1atm1LedGadd45atm1AjfGadd45atm1AjfCdkn1atm1LedGadd45atm1Ajf
• exencephaly_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0000914EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• decreased mitotic index_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0004759EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• increased fibroblast proliferation_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0011703EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• aneuploidy_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0004024EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf
• abnormal cell cycle checkpoint function_Cdkn1a<tm1Led>/Cdkn1a<tm1Led>
  http://metadb.riken.jp/0004045I129S6SvEvTacCdkn1atm1LedCdkn1atm1LedCdkn1atm1Led
• abnormal chromosome morphology_Gadd45a<tm1Ajf>/Gadd45a<tm1Ajf>
  http://metadb.riken.jp/0003702EI129P2OlaHsdC57BL6orI129X1SvJC57BL6Gadd45atm1AjfGadd45atm1AjfGadd45atm1Ajf

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cell physiology in RBRC09248
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010233
• abnormal chromosome number in RBRC09248
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010230
• increased fibroblast proliferation in RBRC09248
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010238
• decreased sensitivity to induced cell death in RBRC09248
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010235