T. Iwata, et.al., A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos., Human molecular genetics, 2000, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/10861287

T. Iwata, et.al., A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos., Human molecular genetics, 2000, 9

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Fgfr3<tm4.1Cxd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2135676
• Fgfr3<tm4Cxd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2135675

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• impaired lung alveolus development_Fgfr3<tm4Cxd>/Fgfr3<+>,Tg(Col2a1-cre)1Bhr/0
  http://metadb.riken.jp/0006027I129S6SvEvTacC57BL6NIHBlackSwissSJLFgfr3tm4CxdFgfr3TgCol2a1cre1Bhr0Fgfr3TgCol2a1cre1BhrFgfr3tm4Cxd
• abnormal long bone epiphyseal plate proliferative zone_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0003662I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal long bone epiphyseal plate morphology_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0003055I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• neonatal lethality, incomplete penetrance_Fgfr3<tm4Cxd>/Fgfr3<+>,Tg(Col2a1-cre)1Bhr/0
  http://metadb.riken.jp/0011088I129S6SvEvTacC57BL6NIHBlackSwissSJLFgfr3tm4CxdFgfr3TgCol2a1cre1Bhr0Fgfr3TgCol2a1cre1BhrFgfr3tm4Cxd
• abnormal skeleton morphology_Fgfr3<tm4Cxd>/Fgfr3<+>,Tg(Col2a1-cre)1Bhr/0
  http://metadb.riken.jp/0005508I129S6SvEvTacC57BL6NIHBlackSwissSJLFgfr3tm4CxdFgfr3TgCol2a1cre1Bhr0Fgfr3TgCol2a1cre1BhrFgfr3tm4Cxd
• increased fibroblast proliferation_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0011703I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal costal cartilage morphology_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0006432I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• increased diameter of long bones_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0008151I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• bowed ulna_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0004361I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• short ulna_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0004359I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal thoracic cage shape_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0010099I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• decreased length of long bones_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0004686I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal long bone diaphysis morphology_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0004214I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• neonatal lethality, complete penetrance_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0011087I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal long bone hypertrophic chondrocyte zone_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0000165I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal head shape_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0011495I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal chondrocyte morphology_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0000166I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• short tibia_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0002764I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• short femur_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0003109I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• impaired lung alveolus development_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0006027I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal ulna morphology_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0005108I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• small thoracic cage_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0010103I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal long bone morphology_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0003723I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal osteoblast physiology_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0005006I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal bone ossification_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0008271I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• short limbs_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0000547I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• failure of sternum ossification_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0008278I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• abnormal spine curvature_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0004174I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• wide sternum_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0012279I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd
• short humerus_Fgfr3<tm4.1Cxd>/Fgfr3<+>
  http://metadb.riken.jp/0004351I129S6SvEvTacNIHBlackSwissFgfr3tm41CxdFgfr3Fgfr3Fgfr3tm41Cxd

class

http://purl.org/net/cito/citesAsAuthority

• Fgfr3<tm4.1Cxd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2135676
• Fgfr3<tm4Cxd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2135675