E. Latres, et.al., Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis., The EMBO journal, 2000, 19

http://rdf.ncbi.nlm.nih.gov/pubmed/10880462

E. Latres, et.al., Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis., The EMBO journal, 2000, 19

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1933761
• Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1933760

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal lymph node germinal center morphology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0008522I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• abnormal mammary gland morphology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0000627I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• increased mature B cell number_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0008210I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• lymphoid hyperplasia_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0000688I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• kidney cysts_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0003675I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• increased T cell derived lymphoma incidence_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0002024I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• increased hemangiosarcoma incidence_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0003667I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• pituitary gland hyperplasia_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0000635I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• mammary gland hyperplasia_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0000630I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• cortical renal glomerulopathies_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0000523I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• increased sarcoma incidence_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0002032I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• increased body size_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0001264I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• extramedullary hematopoiesis_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0000240I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• premature death_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0002083I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• increased renal carcinoma incidence_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0010384I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• abnormal Langerhans cell morphology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0008117I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• kidney cysts_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0003675I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• increased adenocarcinoma incidence_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0009308I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• increased spleen white pulp amount_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0008478I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• abnormal lymph node secondary follicle morphology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0002346I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• abnormal lymphocyte morphology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0002619I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• extramedullary hematopoiesis_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0000240I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• abnormal testis morphology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0001146I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• dilated rete testis_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0006423I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• premature death_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0002083I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• enlarged testis_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0001148I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• increased testis tumor incidence_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0006262I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• enlarged lymph nodes_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0000702I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• increased body weight_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0001260I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• lymph node hyperplasia_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0008102I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• increased sarcoma incidence_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0002032I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• abnormal cell physiology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0005621I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• increased B cell derived lymphoma incidence_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0002023I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• spleen hyperplasia_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0000693I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• increased tumor incidence_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0002020I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• increased tumor incidence_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0002020I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• seminiferous tubule degeneration_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0001154I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• abnormal lymphocyte morphology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0002619I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• abnormal mammary gland epithelium morphology_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0009504I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• abnormal spleen morphology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0000689I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• increased testis tumor incidence_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0006262I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• pancreas cysts_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0003336I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• increased pituitary adenoma incidence_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0002041I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• lymphoid hyperplasia_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0000688I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• increased lymphoma incidence_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0012431I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• lymph node hyperplasia_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0008102I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• increased pheochromocytoma incidence_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0002050I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• kidney cortex cysts_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0000522I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• increased fibroblast proliferation_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0011703I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• increased pituitary adenoma incidence_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0002041I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• lymphoid hyperplasia_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0000688I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• enlarged spleen_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0000691I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• increased fibroblast proliferation_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0011703I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• abnormal lymph node medulla morphology_Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0002348I129S1SvC57BL6Cdkn2ctm1BbdCdkn2ctm1BbdCdkn2ctm1Bbd
• abnormal spleen marginal zone morphology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0002362I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd
• enlarged spleen_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Cdkn2c<tm1Bbd>/Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/0000691I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2ctm1BbdCdkn2ctm1BbdCdkn2btm1BbdCdkn2ctm1Bbd
• abnormal cell physiology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/0005621I129S1SvC57BL6Cdkn2btm1BbdCdkn2btm1BbdCdkn2btm1Bbd

class

http://purl.org/net/cito/citesAsAuthority

• Cdkn2c<tm1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1933761
• Cdkn2b<tm1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1933760