J P. Silva, et.al., Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes., Nature genetics, 2000, 26

http://rdf.ncbi.nlm.nih.gov/pubmed/11062475

J P. Silva, et.al., Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes., Nature genetics, 2000, 26

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• absent pancreatic beta cells_Tfam<tm1Lrsn>/Tfam<tm1Lrsn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0009174I129S1Sv129X1SvJC57BL6DBATfamtm1LrsnTfamtm1LrsnTgIns2cre25Mgn0Tfamtm1LrsnTgIns2cre25Mgn
• decreased insulin secretion_Tfam<tm1Lrsn>/Tfam<tm1Lrsn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0003059I129S1Sv129X1SvJC57BL6DBATfamtm1LrsnTfamtm1LrsnTgIns2cre25Mgn0Tfamtm1LrsnTgIns2cre25Mgn
• increased insulin sensitivity_Tfam<tm1Lrsn>/Tfam<tm1Lrsn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0002891I129S1Sv129X1SvJC57BL6DBATfamtm1LrsnTfamtm1LrsnTgIns2cre25Mgn0Tfamtm1LrsnTgIns2cre25Mgn
• decreased mitochondrial DNA content_Tfam<tm1Lrsn>/Tfam<tm1Lrsn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0011639I129S1Sv129X1SvJC57BL6DBATfamtm1LrsnTfamtm1LrsnTgIns2cre25Mgn0Tfamtm1LrsnTgIns2cre25Mgn
• abnormal respiratory electron transport chain_Tfam<tm1Lrsn>/Tfam<tm1Lrsn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0010955I129S1Sv129X1SvJC57BL6DBATfamtm1LrsnTfamtm1LrsnTgIns2cre25Mgn0Tfamtm1LrsnTgIns2cre25Mgn
• abnormal mitochondrion morphology_Tfam<tm1Lrsn>/Tfam<tm1Lrsn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0006035I129S1Sv129X1SvJC57BL6DBATfamtm1LrsnTfamtm1LrsnTgIns2cre25Mgn0Tfamtm1LrsnTgIns2cre25Mgn
• abnormal circulating insulin level_Tfam<tm1Lrsn>/Tfam<tm1Lrsn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0001560I129S1Sv129X1SvJC57BL6DBATfamtm1LrsnTfamtm1LrsnTgIns2cre25Mgn0Tfamtm1LrsnTgIns2cre25Mgn