G M. Doody, et.al., Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation., Nature immunology, 2001, 2

http://rdf.ncbi.nlm.nih.gov/pubmed/11376342

G M. Doody, et.al., Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation., Nature immunology, 2001, 2

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Vav2<tm1Tnr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2387845

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased CD4-positive, alpha beta T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008075I129P2OlaHsd129S2SvPasVav1tm1TybVav1tm1TybVav2tm1TnrVav2tm1TnrVav1tm1TybVav2tm1Tnr
• decreased follicular B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008174I129P2OlaHsd129S2SvPasVav1tm1TybVav1tm1TybVav2tm1TnrVav2tm1TnrVav1tm1TybVav2tm1Tnr
• decreased IgG1 level_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008495I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• decreased immature B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008215I129P2OlaHsd129S2SvPasVav1tm1TybVav1tm1TybVav2tm1TnrVav2tm1TnrVav1tm1TybVav2tm1Tnr
• decreased spleen germinal center number_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008482I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• decreased IgM level_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0001806I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• decreased B cell number_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0005017I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• decreased B cell proliferation_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0005093I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• abnormal class switch recombination_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0004816I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• decreased IgG3 level_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008498I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• decreased B cell proliferation_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0005093I129P2OlaHsd129S2SvPasVav1tm1TybVav1tm1TybVav2tm1TnrVav2tm1TnrVav1tm1TybVav2tm1Tnr
• decreased CD8-positive, alpha-beta T cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008079I129P2OlaHsd129S2SvPasVav1tm1TybVav1tm1TybVav2tm1TnrVav2tm1TnrVav1tm1TybVav2tm1Tnr
• decreased IgG2b level_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008497I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• abnormal B cell physiology_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0002459I129P2OlaHsd129S2SvPasVav1tm1TybVav1tm1TybVav2tm1TnrVav2tm1TnrVav1tm1TybVav2tm1Tnr
• decreased mature B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008211I129P2OlaHsd129S2SvPasVav1tm1TybVav1tm1TybVav2tm1TnrVav2tm1TnrVav1tm1TybVav2tm1Tnr
• decreased B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0005017I129P2OlaHsd129S2SvPasVav1tm1TybVav1tm1TybVav2tm1TnrVav2tm1TnrVav1tm1TybVav2tm1Tnr

class

http://purl.org/net/cito/citesAsAuthority

• Vav2<tm1Tnr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2387845