Imran N. Mungrue, et.al., Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death., The Journal of clinical investigation, 2002, 109

http://rdf.ncbi.nlm.nih.gov/pubmed/11901182

Imran N. Mungrue, et.al., Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death., The Journal of clinical investigation, 2002, 109

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-NOS2,-lacZ)240iMhus
  http://metadb.riken.jp/db/mgi_rdf/MGI:4837700

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-NOS2,-lacZ)240iMhus
  http://metadb.riken.jp/db/mgi_rdf/MGI:4837700

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• dilated heart ventricle_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0008022IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• lethargy_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0005202IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• abnormal heart left ventricle morphology_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0003921IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• cardiac muscle necrosis_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0010632IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• congestive heart failure_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0006138IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• edema_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0001785IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• increased heart ventricle size_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0008772IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• abnormal atrioventricular node morphology_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0004114IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• respiratory distress_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0001954IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• atrioventricular block_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0010519IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• enlarged heart_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0000274IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• cardiac interstitial fibrosis_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0005608IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• absent heartbeat_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0004086IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• abnormal cardiovascular system physiology_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0001544IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• prolonged P wave_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0004071IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• increased heart weight_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0002833IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• prolonged PR interval_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0003896IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• premature death_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0002083IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• ventricular tachycardia_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0008950IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• heart block_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0010559IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• heart inflammation_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0001853IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• no abnormal phenotype detected_Tg(tetO-NOS2,-lacZ)240iMhus/Tg(tetO-NOS2,-lacZ)240iMhus
  http://metadb.riken.jp/0002169C57BL6TgtetONOS2lacZ240iMhusTgtetONOS2lacZ240iMhusTgtetONOS2lacZ240iMhusTgtetONOS2lacZ240iMhus
• abnormal P wave_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0004070IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf
• increased body weight_Tg(Myh6-tTA)6Smbf/0,Tg(tetO-NOS2,-lacZ)240iMhus/0
  http://metadb.riken.jp/0001260IC57BL6CBATgMyh6tTA6Smbf0TgtetONOS2lacZ240iMhus0TgtetONOS2lacZ240iMhusTgMyh6tTA6Smbf