Seung K. Kim, et.al., Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus., Nature genetics, 2002, 30

http://rdf.ncbi.nlm.nih.gov/pubmed/11912494

Seung K. Kim, et.al., Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus., Nature genetics, 2002, 30

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pancreatic islet morphology_Pbx1<tm1Mlc>/Pbx1<+>
  http://metadb.riken.jp/0005215I129S6SvEvTacC57BL6Pbx1tm1MlcPbx1Pbx1Pbx1tm1Mlc
• increased urine glucose level_Pdx1<tm1Cvw>/Pdx1<+>,Pbx1<tm1Mlc>/Pbx1<+>
  http://metadb.riken.jp/0001759I129S6SvEvTacC57BL6Pdx1tm1CvwPdx1Pbx1tm1MlcPbx1Pdx1Pbx1tm1MlcPdx1tm1CvwPbx1
• increased insulin sensitivity_Pbx1<tm1Mlc>/Pbx1<+>
  http://metadb.riken.jp/0002891I129S6SvEvTacC57BL6Pbx1tm1MlcPbx1Pbx1Pbx1tm1Mlc
• increased insulin sensitivity_Pdx1<tm1Cvw>/Pdx1<+>,Pbx1<tm1Mlc>/Pbx1<+>
  http://metadb.riken.jp/0002891I129S6SvEvTacC57BL6Pdx1tm1CvwPdx1Pbx1tm1MlcPbx1Pdx1Pbx1tm1MlcPdx1tm1CvwPbx1
• absent pancreatic islets_Pbx1<tm1Mlc>/Pbx1<tm1Mlc>
  http://metadb.riken.jp/0009173I129S6SvEvTacC57BL6Pbx1tm1MlcPbx1tm1MlcPbx1tm1Mlc
• decreased insulin secretion_Pbx1<tm1Mlc>/Pbx1<+>
  http://metadb.riken.jp/0003059I129S6SvEvTacC57BL6Pbx1tm1MlcPbx1Pbx1Pbx1tm1Mlc
• decreased insulin secretion_Pdx1<tm1Cvw>/Pdx1<+>,Pbx1<tm1Mlc>/Pbx1<+>
  http://metadb.riken.jp/0003059I129S6SvEvTacC57BL6Pdx1tm1CvwPdx1Pbx1tm1MlcPbx1Pdx1Pbx1tm1MlcPdx1tm1CvwPbx1
• weight loss_Pdx1<tm1Cvw>/Pdx1<+>,Pbx1<tm1Mlc>/Pbx1<+>
  http://metadb.riken.jp/0001263I129S6SvEvTacC57BL6Pdx1tm1CvwPdx1Pbx1tm1MlcPbx1Pdx1Pbx1tm1MlcPdx1tm1CvwPbx1
• impaired glucose tolerance_Pdx1<tm1Cvw>/Pdx1<+>,Pbx1<tm1Mlc>/Pbx1<+>
  http://metadb.riken.jp/0005293I129S6SvEvTacC57BL6Pdx1tm1CvwPdx1Pbx1tm1MlcPbx1Pdx1Pbx1tm1MlcPdx1tm1CvwPbx1
• exocrine pancreas hypoplasia_Pbx1<tm1Mlc>/Pbx1<tm1Mlc>
  http://metadb.riken.jp/0005492I129S6SvEvTacC57BL6Pbx1tm1MlcPbx1tm1MlcPbx1tm1Mlc
• disorganized pancreatic islets_Pdx1<tm1Cvw>/Pdx1<+>,Pbx1<tm1Mlc>/Pbx1<+>
  http://metadb.riken.jp/0009254I129S6SvEvTacC57BL6Pdx1tm1CvwPdx1Pbx1tm1MlcPbx1Pdx1Pbx1tm1MlcPdx1tm1CvwPbx1
• hyperglycemia_Pdx1<tm1Cvw>/Pdx1<+>,Pbx1<tm1Mlc>/Pbx1<+>
  http://metadb.riken.jp/0001559I129S6SvEvTacC57BL6Pdx1tm1CvwPdx1Pbx1tm1MlcPbx1Pdx1Pbx1tm1MlcPdx1tm1CvwPbx1
• impaired glucose tolerance_Pbx1<tm1Mlc>/Pbx1<+>
  http://metadb.riken.jp/0005293I129S6SvEvTacC57BL6Pbx1tm1MlcPbx1Pbx1Pbx1tm1Mlc