Domenico. Migliorini, et.al., Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development., Molecular and cellular biology, 2002, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/12101245

Domenico. Migliorini, et.al., Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development., Molecular and cellular biology, 2002, 22

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal neural tube closure_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0003720I129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex
• abnormal cell cycle checkpoint function_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0004045I129S2SvPasTrp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• decreased embryo size_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0001698I129S2SvPas129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexTrp53tm1TyjTrp53Trp53tm1TyjTrp53Mdm4GtVICTR207Lex
• decreased embryo size_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0001698I129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex
• embryonic lethality during organogenesis, complete penetrance_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0011098I129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex
• telencephalon hypoplasia_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0000785I129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex
• increased fibroblast proliferation_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0011703I129S2SvPas129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexTrp53tm1TyjTrp53tm1TyjMdm4GtVICTR207LexTrp53tm1Tyj
• decreased cell proliferation_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0000352I129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex
• abnormal cell cycle checkpoint function_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0004045I129S2SvPas129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexTrp53tm1TyjTrp53tm1TyjMdm4GtVICTR207LexTrp53tm1Tyj
• increased fibroblast proliferation_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0011703I129S2SvPasTrp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• decreased cellular sensitivity to ultraviolet irradiation_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0008411I129S2SvPas129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexTrp53tm1TyjTrp53tm1TyjMdm4GtVICTR207LexTrp53tm1Tyj
• preweaning lethality, complete penetrance_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0011100I129S2SvPas129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexTrp53tm1TyjTrp53Trp53tm1TyjTrp53Mdm4GtVICTR207Lex
• pallor_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0003717I129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex
• abnormal cell cycle_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0003077I129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex
• dilated lateral ventricles_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0000825I129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex
• decreased cellular sensitivity to ultraviolet irradiation_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0008411I129S2SvPasTrp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• abnormal nervous system development_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0003861I129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex