Liu. Cao, et.al., Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform., Genes & development, 2003, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/12533509

Liu. Cao, et.al., Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform., Genes & development, 2003, 17

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased subcutaneous adipose tissue amount_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0008844I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• kyphosis_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0000160I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• osteoporosis_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0000066I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• increased physiological sensitivity to xenobiotic_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0008873I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• decreased body weight_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0001262I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• abnormal trabecular bone morphology_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0000130I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• decreased total body fat amount_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0010025I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• muscular atrophy_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0002269I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• premature death_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0002083I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• premature aging_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0003786I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• neonatal lethality, complete penetrance_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Cdkn1a<tm1Led>/Cdkn1a<tm1Led>
  http://metadb.riken.jp/0011087I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdCdkn1atm1LedCdkn1atm1LedBrca1tm21CxdCdkn1atm1Led
• impaired wound healing_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0001792I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• delayed hair regrowth_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0000423I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• thin dermal layer_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0001244I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• decreased cell proliferation_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0000352I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• abnormal bone structure_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0003795I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• decreased compact bone thickness_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0000135I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53
• increased tumor incidence_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>
  http://metadb.riken.jp/0002020I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Trp53tm1BrdBrca1tm21CxdTrp53