Carmen. Guerra, et.al., Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context., Cancer cell, 2003, 4

http://rdf.ncbi.nlm.nih.gov/pubmed/12957286

Carmen. Guerra, et.al., Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context., Cancer cell, 2003, 4

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3772332
• Kras<tm1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3582830

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased papilloma incidence_Cdk4<tm1.1Bbd>/Cdk4<+>,Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0002014I129S1Sv129X1SvJBALBcJC57BL6Cdk4tm11BbdCdk4Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasCdk4tm11BbdTgCMVcre1CgnCdk4
• respiratory distress_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0001954I129S1Sv129X1SvJBALBcJC57BL6Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasTgCMVcre1Cgn
• respiratory distress_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre/ERT)1Ipc/0
  http://metadb.riken.jp/0001954I129S1Sv129X1SvJC57BL6SJLKrastm1BbdKrasTgCMVcreERT1Ipc0KrasKrastm1BbdTgCMVcreERT1Ipc
• increased sarcoma incidence_Cdk4<tm1.1Bbd>/Cdk4<+>,Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0002032I129S1Sv129X1SvJBALBcJC57BL6Cdk4tm11BbdCdk4Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasCdk4tm11BbdTgCMVcre1CgnCdk4
• abnormal pancreatic duct morphology_Cdk4<tm1.1Bbd>/Cdk4<+>,Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0009143I129S1Sv129X1SvJBALBcJC57BL6Cdk4tm11BbdCdk4Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasCdk4tm11BbdTgCMVcre1CgnCdk4
• embryonic lethality during organogenesis, complete penetrance_Kras<tm1Bbd>/Kras<tm1Bbd>
  http://metadb.riken.jp/0011098I129S1Sv129X1SvJC57BL6Krastm1BbdKrastm1BbdKrastm1Bbd
• increased hemangiosarcoma incidence_Cdk4<tm1.1Bbd>/Cdk4<+>,Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0003667I129S1Sv129X1SvJBALBcJC57BL6Cdk4tm11BbdCdk4Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasCdk4tm11BbdTgCMVcre1CgnCdk4
• increased lung adenoma incidence_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0002048I129S1Sv129X1SvJBALBcJC57BL6Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasTgCMVcre1Cgn
• increased lung adenocarcinoma incidence_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre/ERT)1Ipc/0
  http://metadb.riken.jp/0002027I129S1Sv129X1SvJC57BL6SJLKrastm1BbdKrasTgCMVcreERT1Ipc0KrasKrastm1BbdTgCMVcreERT1Ipc
• Harderian gland hyperplasia_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre/ERT)1Ipc/0
  http://metadb.riken.jp/0013443I129S1Sv129X1SvJC57BL6SJLKrastm1BbdKrasTgCMVcreERT1Ipc0KrasKrastm1BbdTgCMVcreERT1Ipc
• premature death_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre/ERT)1Ipc/0
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6SJLKrastm1BbdKrasTgCMVcreERT1Ipc0KrasKrastm1BbdTgCMVcreERT1Ipc
• increased lung adenocarcinoma incidence_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0002027I129S1Sv129X1SvJBALBcJC57BL6Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasTgCMVcre1Cgn
• increased lung adenoma incidence_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre/ERT)1Ipc/0
  http://metadb.riken.jp/0002048I129S1Sv129X1SvJC57BL6SJLKrastm1BbdKrasTgCMVcreERT1Ipc0KrasKrastm1BbdTgCMVcreERT1Ipc
• increased papilloma incidence_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0002014I129S1Sv129X1SvJBALBcJC57BL6Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasTgCMVcre1Cgn
• premature death_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJBALBcJC57BL6Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasTgCMVcre1Cgn
• prenatal lethality, incomplete penetrance_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0011101I129S1Sv129X1SvJBALBcJC57BL6Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasTgCMVcre1Cgn
• increased pituitary adenoma incidence_Cdk4<tm1.1Bbd>/Cdk4<+>,Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0002041I129S1Sv129X1SvJBALBcJC57BL6Cdk4tm11BbdCdk4Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasCdk4tm11BbdTgCMVcre1CgnCdk4
• abnormal fibroblast proliferation_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre/ERT)1Ipc/0
  http://metadb.riken.jp/0011702I129S1Sv129X1SvJC57BL6SJLKrastm1BbdKrasTgCMVcreERT1Ipc0KrasKrastm1BbdTgCMVcreERT1Ipc
• abnormal cell proliferation_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0000350I129S1Sv129X1SvJBALBcJC57BL6Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasTgCMVcre1Cgn
• increased sarcoma incidence_Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0002032I129S1Sv129X1SvJBALBcJC57BL6Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasTgCMVcre1Cgn
• increased lung adenoma incidence_Cdk4<tm1.1Bbd>/Cdk4<+>,Kras<tm1Bbd>/Kras<+>,Tg(CMV-cre)1Cgn/?
  http://metadb.riken.jp/0002048I129S1Sv129X1SvJBALBcJC57BL6Cdk4tm11BbdCdk4Krastm1BbdKrasTgCMVcre1CgnKrastm1BbdKrasCdk4tm11BbdTgCMVcre1CgnCdk4

class

http://purl.org/net/cito/citesAsAuthority

• Polr2a<tm1(cre/ERT2)Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3772332
• Kras<tm1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3582830