John F. Elliott, et.al., Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice., Proceedings of the National Academy of Sciences of the United States of America, 2003, 100

http://rdf.ncbi.nlm.nih.gov/pubmed/14570980

John F. Elliott, et.al., Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice., Proceedings of the National Academy of Sciences of the United States of America, 2003, 100

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• myocardial necrosis_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0006085NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• dilated cardiomyopathy_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0002795NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• atrioventricular block_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0010519NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• heart inflammation_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0001853NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• premature death_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0002083NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• myositis_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0004510NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• decreased ventricle muscle contractility_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0005598NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• lung inflammation_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0001861NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• abnormal heart electrocardiography waveform feature_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0010508NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• abnormal pulmonary vein morphology_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0002726NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• salivary gland inflammation_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0001870NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• cardiac fibrosis_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0003141NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• hyperglycemia_Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0001559NODMrkTacTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11Ell
• mitral valve prolapse_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0006120NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell
• autoimmune response_H2-Ab1<tm1Gru>/H2-Ab1<tm1Gru>,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
  http://metadb.riken.jp/0001844NODCgH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11EllTgCD2CD4HLADQA1HLADQB11EllH2Ab1tm1GruTgCD2CD4HLADQA1HLADQB11Ell