Joseph T. Opferman, et.al., Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1., Nature, 2003, 426

http://rdf.ncbi.nlm.nih.gov/pubmed/14668867

Joseph T. Opferman, et.al., Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1., Nature, 2003, 426

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Mcl1<tm2Sjk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2684150
• Mcl1<tm3Sjk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2684151

class

http://purl.org/net/cito/citesAsAuthority

• Mcl1<tm2Sjk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2684150
• Mcl1<tm3Sjk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2684151

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• arrested B cell differentiation_Cd19<tm1(cre)Cgn>/Cd19<+>,Mcl1<tm2Sjk>/Mcl1<tm3Sjk>
  http://metadb.riken.jp/0001802I129P2OlaHsd129X1SvJCd19tm1creCgnCd19Mcl1tm2SjkMcl1tm3SjkMcl1tm2SjkCd19tm1creCgnMcl1tm3SjkCd19
• no abnormal phenotype detected_Mcl1<tm3Sjk>/Mcl1<tm3Sjk>
  http://metadb.riken.jp/0002169I129X1SvJMcl1tm3SjkMcl1tm3SjkMcl1tm3Sjk
• decreased B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Mcl1<tm2Sjk>/Mcl1<tm3Sjk>
  http://metadb.riken.jp/0005017I129P2OlaHsd129X1SvJCd19tm1creCgnCd19Mcl1tm2SjkMcl1tm3SjkMcl1tm2SjkCd19tm1creCgnMcl1tm3SjkCd19
• decreased double-positive T cell number_Mcl1<tm2Sjk>/Mcl1<tm3Sjk>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005092I129X1SvJC57BL6DBA2Mcl1tm2SjkMcl1tm3SjkTgLckcre1Cwi0Mcl1tm3SjkMcl1tm2SjkTgLckcre1Cwi
• arrested T cell differentiation_Mcl1<tm2Sjk>/Mcl1<tm3Sjk>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001825I129X1SvJC57BL6DBA2Mcl1tm2SjkMcl1tm3SjkTgLckcre1Cwi0Mcl1tm3SjkMcl1tm2SjkTgLckcre1Cwi
• increased T cell apoptosis_Mcl1<tm2Sjk>/Mcl1<tm3Sjk>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0006413I129X1SvJC57BL6DBA2Mcl1tm2SjkMcl1tm3SjkTgLckcre1Cwi0Mcl1tm3SjkMcl1tm2SjkTgLckcre1Cwi
• decreased thymocyte number_Mcl1<tm2Sjk>/Mcl1<tm3Sjk>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0000715I129X1SvJC57BL6DBA2Mcl1tm2SjkMcl1tm3SjkTgLckcre1Cwi0Mcl1tm3SjkMcl1tm2SjkTgLckcre1Cwi
• increased B cell apoptosis_Cd19<tm1(cre)Cgn>/Cd19<+>,Mcl1<tm2Sjk>/Mcl1<tm3Sjk>
  http://metadb.riken.jp/0008782I129P2OlaHsd129X1SvJCd19tm1creCgnCd19Mcl1tm2SjkMcl1tm3SjkMcl1tm2SjkCd19tm1creCgnMcl1tm3SjkCd19
• decreased double-negative T cell number_Mcl1<tm2Sjk>/Mcl1<tm3Sjk>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005089I129X1SvJC57BL6DBA2Mcl1tm2SjkMcl1tm3SjkTgLckcre1Cwi0Mcl1tm3SjkMcl1tm2SjkTgLckcre1Cwi
• absent late pro-B cells_Cd19<tm1(cre)Cgn>/Cd19<+>,Mcl1<tm2Sjk>/Mcl1<tm3Sjk>
  http://metadb.riken.jp/0005434I129P2OlaHsd129X1SvJCd19tm1creCgnCd19Mcl1tm2SjkMcl1tm3SjkMcl1tm2SjkCd19tm1creCgnMcl1tm3SjkCd19
• absent early pro-B cells_Cd19<tm1(cre)Cgn>/Cd19<+>,Mcl1<tm2Sjk>/Mcl1<tm3Sjk>
  http://metadb.riken.jp/0005433I129P2OlaHsd129X1SvJCd19tm1creCgnCd19Mcl1tm2SjkMcl1tm3SjkMcl1tm2SjkCd19tm1creCgnMcl1tm3SjkCd19
• absent pre-B cells_Cd19<tm1(cre)Cgn>/Cd19<+>,Mcl1<tm2Sjk>/Mcl1<tm3Sjk>
  http://metadb.riken.jp/0000238I129P2OlaHsd129X1SvJCd19tm1creCgnCd19Mcl1tm2SjkMcl1tm3SjkMcl1tm2SjkCd19tm1creCgnMcl1tm3SjkCd19
• decreased B cell number_Mcl1<tm2Sjk>/Mcl1<tm3Sjk>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005017I129X1SvJC57BL6CBAMcl1tm2SjkMcl1tm3SjkTgMx1cre1Cgn0TgMx1cre1CgnMcl1tm2SjkMcl1tm3Sjk
• abnormal B cell differentiation_Cd19<tm1(cre)Cgn>/Cd19<+>,Mcl1<tm2Sjk>/Mcl1<tm3Sjk>
  http://metadb.riken.jp/0002144I129P2OlaHsd129X1SvJCd19tm1creCgnCd19Mcl1tm2SjkMcl1tm3SjkMcl1tm2SjkCd19tm1creCgnMcl1tm3SjkCd19
• decreased T cell number_Mcl1<tm2Sjk>/Mcl1<tm3Sjk>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005018I129X1SvJC57BL6DBA2Mcl1tm2SjkMcl1tm3SjkTgLckcre1Cwi0Mcl1tm3SjkMcl1tm2SjkTgLckcre1Cwi
• decreased T cell number_Mcl1<tm2Sjk>/Mcl1<tm3Sjk>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005018I129X1SvJC57BL6CBAMcl1tm2SjkMcl1tm3SjkTgMx1cre1Cgn0TgMx1cre1CgnMcl1tm2SjkMcl1tm3Sjk