Xudong. Yang, et.al., Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway., Developmental biology, 2004, 269

http://rdf.ncbi.nlm.nih.gov/pubmed/15081359

Xudong. Yang, et.al., Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway., Developmental biology, 2004, 269

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(ACTB-NOTCH1)1Shn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3044583
• Tg(Actb-NOTCH1)2Shn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3044584
• Notch1<tm2Rko>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3044585

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased brain size_Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000774B6CgTgNescre1KlnTgACTBNOTCH11ShnTgACTBNOTCH11Shn0TgNescre1Kln0TgNescre1KlnTgACTBNOTCH11Shn
• abnormal apoptosis_Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0001648I129S2SvPasC57BL6JTgACTBNOTCH11Shn0TgNescre1Kln0Trp53tm1TyjTrp53Trp53Trp53tm1TyjTgACTBNOTCH11ShnTgNescre1Kln
• abnormal cortical ventricular zone morphology_Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008458B6CgTgNescre1KlnTgACTBNOTCH11ShnTgACTBNOTCH11Shn0TgNescre1Kln0TgNescre1KlnTgACTBNOTCH11Shn
• abnormal neuron apoptosis_Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003202B6CgTgNescre1KlnTgACTBNOTCH11ShnTgACTBNOTCH11Shn0TgNescre1Kln0TgNescre1KlnTgACTBNOTCH11Shn
• prenatal lethality, incomplete penetrance_Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0011101I129S2SvPasC57BL6JTgACTBNOTCH11Shn0TgNescre1Kln0Trp53tm1TyjTrp53tm1TyjTgNescre1KlnTgACTBNOTCH11ShnTrp53tm1Tyj
• abnormal apoptosis_Psen1<tm1Shn>/Psen1<tm1Shn>
  http://metadb.riken.jp/0001648NSPsen1tm1ShnPsen1tm1ShnPsen1tm1Shn
• small embryonic telencephalon_Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000936B6CgTgNescre1KlnTgACTBNOTCH11ShnTgACTBNOTCH11Shn0TgNescre1Kln0TgNescre1KlnTgACTBNOTCH11Shn
• increased neuron number_Notch1<tm2Rko>/Notch1<tm2Rko>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008947I129X1SvJC57BL6JSJLNotch1tm2RkoNotch1tm2RkoTgNescre1Kln0TgNescre1KlnNotch1tm2Rko
• perinatal lethality, complete penetrance_Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011089B6CgTgNescre1KlnTgACTBNOTCH11ShnTgACTBNOTCH11Shn0TgNescre1Kln0TgNescre1KlnTgACTBNOTCH11Shn
• prenatal lethality, incomplete penetrance_Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011101B6CgTgNescre1KlnTgACTBNOTCH11ShnTgACTBNOTCH11Shn0TgNescre1Kln0TgNescre1KlnTgACTBNOTCH11Shn
• abnormal apoptosis_Tg(Actb-NOTCH1)2Shn/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001648IC57BL6JSJLTgActbNOTCH12Shn0TgNescre1Kln0TgActbNOTCH12ShnTgNescre1Kln
• abnormal apoptosis_Notch1<tm2Rko>/Notch1<tm2Rko>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001648I129X1SvJC57BL6JSJLNotch1tm2RkoNotch1tm2RkoTgNescre1Kln0TgNescre1KlnNotch1tm2Rko
• decreased neuron number_Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008948B6CgTgNescre1KlnTgACTBNOTCH11ShnTgACTBNOTCH11Shn0TgNescre1Kln0TgNescre1KlnTgACTBNOTCH11Shn

class

http://purl.org/net/cito/citesAsAuthority

• Tg(ACTB-NOTCH1)1Shn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3044583
• Tg(Actb-NOTCH1)2Shn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3044584
• Notch1<tm2Rko>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3044585