Daniel. Goti, et.al., A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/15537899

Daniel. Goti, et.al., A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 24

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/db/mgi_rdf/MGI:3798042
• Tg(Prnp-ATXN3)AVcg
  http://metadb.riken.jp/db/mgi_rdf/MGI:3798041
• Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/db/mgi_rdf/MGI:3798044

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/db/mgi_rdf/MGI:3798042
• Tg(Prnp-ATXN3)AVcg
  http://metadb.riken.jp/db/mgi_rdf/MGI:3798041
• Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/db/mgi_rdf/MGI:3798044

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• limb grasping_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0001513IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• increased grooming behavior_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0001441IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• no abnormal phenotype detected_Tg(Prnp-ATXN3)AVcg/0
  http://metadb.riken.jp/0002169IC3HHeJC57BL6TgPrnpATXN3AVcg0TgPrnpATXN3AVcg
• hypoactivity_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0001402IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• kyphosis_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0000160IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• neuronal intranuclear inclusions_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0004191IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• kyphosis_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0000160IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• ataxia_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0001393IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• tremors_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0000745IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• weight loss_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0001263IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• impaired coordination_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0001405IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• hypoactivity_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0001402IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• abnormal gait_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0001406IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• increased grooming behavior_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0001441IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• decreased dopaminergic neuron number_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0011448IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• impaired righting response_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0001523IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• decreased grip strength_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0010053IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• weight loss_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0001263IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• neuronal intranuclear inclusions_Tg(Prnp-ATXN3)CVcg/0
  http://metadb.riken.jp/0004191IC3HHeJC57BL6TgPrnpATXN3CVcg0TgPrnpATXN3CVcg
• impaired righting response_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0001523IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• abnormal gait_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0001406IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• tremors_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0000745IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• decreased grip strength_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0010053IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• impaired coordination_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0001405IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• seizures_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0002064IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• limb grasping_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0001513IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• ataxia_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0001393IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg
• seizures_Tg(Prnp-ATXN3)CVcg/Tg(Prnp-ATXN3)CVcg
  http://metadb.riken.jp/0002064IC3HHeJC57BL6TgPrnpATXN3CVcgTgPrnpATXN3CVcgTgPrnpATXN3CVcg
• neuronal intranuclear inclusions_Tg(Prnp-ATXN3)BVcg/Tg(Prnp-ATXN3)BVcg
  http://metadb.riken.jp/0004191IC3HHeJC57BL6TgPrnpATXN3BVcgTgPrnpATXN3BVcgTgPrnpATXN3BVcg