Elsa R. Flores, et.al., Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family., Cancer cell, 2005, 7

http://rdf.ncbi.nlm.nih.gov/pubmed/15837625

Elsa R. Flores, et.al., Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family., Cancer cell, 2005, 7

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased hemangiosarcoma incidence_Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0003667I129S4SvJaeC57BL6Trp73tm1FmcTrp73Trp73tm1FmcTrp73
• increased salivary gland adenoma incidence_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0013537I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• premature aging_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0003786I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• premature death_Trp73<tm1Fmc>/Trp73<tm1Fmc>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6Trp73tm1FmcTrp73tm1FmcTrp73tm1Fmc
• increased sarcoma incidence_Trp53<tm1Tyj>/Trp53<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002032I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp73tm1FmcTrp73Trp73Trp73tm1FmcTrp53Trp53tm1Tyj
• increased hemangiosarcoma incidence_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0003667I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• increased pancreatic acinar cell carcinoma incidence_Trp53<tm1Tyj>/Trp53<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0008780I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp73tm1FmcTrp73Trp73Trp73tm1FmcTrp53Trp53tm1Tyj
• increased tumor incidence_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0002020I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63
• increased lung adenoma incidence_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002048I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• premature death_Trp53<tm1Tyj>/Trp53<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002083I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp73tm1FmcTrp73Trp73Trp73tm1FmcTrp53Trp53tm1Tyj
• increased lung adenocarcinoma incidence_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002027I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• increased T cell derived lymphoma incidence_Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002024I129S4SvJaeC57BL6Trp73tm1FmcTrp73Trp73tm1FmcTrp73
• increased carcinoma incidence_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002038I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• increased tumor incidence_Trp53<tm1Tyj>/Trp53<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002020I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp73tm1FmcTrp73Trp73Trp73tm1FmcTrp53Trp53tm1Tyj
• premature death_Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp63tm1FmcTrp63
• increased T cell derived lymphoma incidence_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0002024I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63
• increased metastatic potential_Trp53<tm1Tyj>/Trp53<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0001272I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp73tm1FmcTrp73Trp73Trp73tm1FmcTrp53Trp53tm1Tyj
• increased squamous cell carcinoma incidence_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0004207I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63
• increased rhabdomyosarcoma incidence_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0002036I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63
• increased metastatic potential_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0001272I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• increased mammary adenocarcinoma incidence_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0001883I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• premature death_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0002083I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63
• increased lung adenocarcinoma incidence_Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002027I129S4SvJaeC57BL6Trp73tm1FmcTrp73Trp73tm1FmcTrp73
• increased urinary bladder transitional cell carcinoma incidence_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0009551I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63
• increased tumor incidence_Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0002020I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp63tm1FmcTrp63
• increased T cell derived lymphoma incidence_Trp53<tm1Tyj>/Trp53<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002024I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp73tm1FmcTrp73Trp73Trp73tm1FmcTrp53Trp53tm1Tyj
• increased tumor incidence_Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002020I129S4SvJaeC57BL6Trp73tm1FmcTrp73Trp73tm1FmcTrp73
• increased tumor incidence_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002020I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• increased squamous cell carcinoma incidence_Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0004207I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp63tm1FmcTrp63
• increased lung adenoma incidence_Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002048I129S4SvJaeC57BL6Trp73tm1FmcTrp73Trp73tm1FmcTrp73
• increased squamous cell carcinoma incidence_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0004207I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• paralysis_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0000753I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• increased mammary adenocarcinoma incidence_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0001883I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63
• increased malignant tumor incidence_Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002018I129S4SvJaeC57BL6Trp73tm1FmcTrp73Trp73tm1FmcTrp73
• increased histiocytic sarcoma incidence_Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0009321I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp63tm1FmcTrp63
• increased chronic myelocytic leukemia incidence_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0005481I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63
• intervertebral disk degeneration_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0004684I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63
• increased lung adenocarcinoma incidence_Trp53<tm1Tyj>/Trp53<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002027I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp73tm1FmcTrp73Trp73Trp73tm1FmcTrp53Trp53tm1Tyj
• increased lung adenoma incidence_Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0002048I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp63tm1FmcTrp63
• intervertebral disk degeneration_Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0004684I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp63tm1FmcTrp63
• increased T cell derived lymphoma incidence_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002024I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• premature aging_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0003786I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63
• intervertebral disk degeneration_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0004684I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• increased hepatocellular carcinoma incidence_Trp53<tm1Tyj>/Trp53<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0003331I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp73tm1FmcTrp73Trp73Trp73tm1FmcTrp53Trp53tm1Tyj
• increased metastatic potential_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0001272I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63
• premature death_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• premature death_Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6Trp73tm1FmcTrp73Trp73tm1FmcTrp73
• increased lung adenocarcinoma incidence_Trp73<tm1Fmc>/Trp73<tm1Fmc>
  http://metadb.riken.jp/0002027I129S4SvJaeC57BL6Trp73tm1FmcTrp73tm1FmcTrp73tm1Fmc
• increased chronic myelocytic leukemia incidence_Trp63<tm1Fmc>/Trp63<+>,Trp73<tm1Fmc>/Trp73<+>
  http://metadb.riken.jp/0005481I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp73tm1FmcTrp73Trp73tm1FmcTrp73Trp63tm1FmcTrp63
• increased malignant tumor incidence_Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0002018I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp63tm1FmcTrp63
• premature aging_Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0003786I129S4SvJaeC57BL6Trp63tm1FmcTrp63Trp63tm1FmcTrp63
• increased osteosarcoma incidence_Trp53<tm1Tyj>/Trp53<+>,Trp63<tm1Fmc>/Trp63<+>
  http://metadb.riken.jp/0003789I129S2SvPas129S4SvJaeC57BL6Trp53tm1TyjTrp53Trp63tm1FmcTrp63Trp53tm1TyjTrp53Trp63tm1FmcTrp63