Julien. Ackermann, et.al., Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background., Cancer research, 2005, 65

http://rdf.ncbi.nlm.nih.gov/pubmed/15899789

Julien. Ackermann, et.al., Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background., Cancer research, 2005, 65

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Tyr-NRAS*Q61K)1Bee
  http://metadb.riken.jp/db/mgi_rdf/MGI:3768645

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Tyr-NRAS*Q61K)1Bee
  http://metadb.riken.jp/db/mgi_rdf/MGI:3768645

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased cutaneous melanoma incidence_Cdkn2a<tm1Rdp>/Cdkn2a<+>,Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0010322I129SvC57BL6DBA2SJLCdkn2atm1RdpCdkn2aTgTyrNRASQ61K1BeeTgTyrNRASQ61K1BeeCdkn2aCdkn2atm1Rdp
• epidermal hyperplasia_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0001222IBALBcC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• abnormal melanocyte morphology_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0002877IC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• hyperpigmentation_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0001188IC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• abnormal hair follicle morphology_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0000377IC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• abnormal dermis papillary layer morphology_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0009545IC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• no abnormal phenotype detected_Tg(Tyr-DT)3Bee/?,Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0002169IC57BL6DBA2TgTyrDT3BeeTgTyrNRASQ61K1BeeTgTyrNRASQ61K1BeeTgTyrDT3Bee
• hyperkeratosis_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0001242IC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• abnormal dermis reticular layer morphology_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0005081IC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• increased cutaneous melanoma incidence_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>
  http://metadb.riken.jp/0010322I129SvC57BL6SJLCdkn2atm1RdpCdkn2atm1RdpCdkn2atm1Rdp
• skin inflammation_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0004947IBALBcC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• epidermal hyperplasia_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0001222IC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• thick epidermis_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0001219IC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• abnormal hair follicle morphology_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0000377IBALBcC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• abnormal optic choroid morphology_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0005098IC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• increased cutaneous melanoma incidence_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0010322I129SvC57BL6DBA2SJLCdkn2atm1RdpCdkn2atm1RdpTgTyrNRASQ61K1BeeCdkn2atm1RdpTgTyrNRASQ61K1Bee
• skin inflammation_Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0004947IC57BL6JDBA2TgTyrNRASQ61K1BeeTgTyrNRASQ61K1Bee
• increased metastatic potential_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0001272I129SvC57BL6DBA2SJLCdkn2atm1RdpCdkn2atm1RdpTgTyrNRASQ61K1BeeCdkn2atm1RdpTgTyrNRASQ61K1Bee
• enlarged lymph nodes_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Tg(Tyr-NRAS*Q61K)1Bee/?
  http://metadb.riken.jp/0000702I129SvC57BL6DBA2SJLCdkn2atm1RdpCdkn2atm1RdpTgTyrNRASQ61K1BeeCdkn2atm1RdpTgTyrNRASQ61K1Bee