Osamu. Takeuchi, et.al., Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease., Proceedings of the National Academy of Sciences of the United States of America, 2005, 102

http://rdf.ncbi.nlm.nih.gov/pubmed/16055554

Osamu. Takeuchi, et.al., Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease., Proceedings of the National Academy of Sciences of the United States of America, 2005, 102

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Bax<tm2Sjk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3589203
• Bcl2l11<tm1Sjk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3589204
• Bcl2l11<tm2Sjk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5543622

class

http://purl.org/net/cito/citesAsAuthority

• Bax<tm2Sjk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3589203
• Bcl2l11<tm1Sjk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3589204
• Bcl2l11<tm2Sjk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5543622

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased IgG level_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002493I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• increased susceptibility to autoimmune disorder_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005350I129P2OlaHsd129S1Sv129X1SvJC57BL6CBABak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkTgMx1cre1Cgn0Baxtm1SjkBak1tm1ThsnTgMx1cre1CgnBaxtm2Sjk
• increased immunoglobulin level_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002461I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• glomerulonephritis_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002743I129P2OlaHsd129S1Sv129X1SvJC57BL6CBABak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkTgMx1cre1Cgn0Baxtm1SjkBak1tm1ThsnTgMx1cre1CgnBaxtm2Sjk
• increased B-2 B cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008206I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• increased pro-B cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008186I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• abnormal B cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002458I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• increased pre-B cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0003132I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• increased follicular B cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008173I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• increased lymphocyte cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005013I129P2OlaHsd129S1Sv129X1SvJC57BL6CBABak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkTgMx1cre1Cgn0Baxtm1SjkBak1tm1ThsnTgMx1cre1CgnBaxtm2Sjk
• increased B cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005014I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• abnormal T cell differentiation_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002145I129P2OlaHsd129S1Sv129X1SvJC57BL6CBABak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkTgMx1cre1Cgn0Baxtm1SjkBak1tm1ThsnTgMx1cre1CgnBaxtm2Sjk
• increased follicular B cell number_Bcl2l11<tm1Sjk>/Bcl2l11<tm1Sjk>
  http://metadb.riken.jp/0008173I129X1SvJBcl2l11tm1SjkBcl2l11tm1SjkBcl2l11tm1Sjk
• increased bone marrow cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0000321I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• arthritis_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002993I129P2OlaHsd129S1Sv129X1SvJC57BL6CBABak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkTgMx1cre1Cgn0Baxtm1SjkBak1tm1ThsnTgMx1cre1CgnBaxtm2Sjk
• increased B cell number_Bcl2l11<tm1Sjk>/Bcl2l11<tm1Sjk>
  http://metadb.riken.jp/0005014I129X1SvJBcl2l11tm1SjkBcl2l11tm1SjkBcl2l11tm1Sjk
• increased B-2 B cell number_Bcl2l11<tm1Sjk>/Bcl2l11<tm1Sjk>
  http://metadb.riken.jp/0008206I129X1SvJBcl2l11tm1SjkBcl2l11tm1SjkBcl2l11tm1Sjk
• increased transitional stage B cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008189I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• increased IgA level_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002495I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• abnormal spleen marginal zone morphology_Bcl2l11<tm1Sjk>/Bcl2l11<tm1Sjk>
  http://metadb.riken.jp/0002362I129X1SvJBcl2l11tm1SjkBcl2l11tm1SjkBcl2l11tm1Sjk
• increased transitional stage B cell number_Bcl2l11<tm1Sjk>/Bcl2l11<tm1Sjk>
  http://metadb.riken.jp/0008189I129X1SvJBcl2l11tm1SjkBcl2l11tm1SjkBcl2l11tm1Sjk
• abnormal B cell physiology_Bcl2l11<tm1Sjk>/Bcl2l11<tm1Sjk>
  http://metadb.riken.jp/0002459I129X1SvJBcl2l11tm1SjkBcl2l11tm1SjkBcl2l11tm1Sjk
• abnormal B cell physiology_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002459I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• increased B cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005014I129P2OlaHsd129S1Sv129X1SvJC57BL6CBABak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkTgMx1cre1Cgn0Baxtm1SjkBak1tm1ThsnTgMx1cre1CgnBaxtm2Sjk
• decreased marginal zone B cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008182I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• premature death_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129S1Sv129X1SvJC57BL6CBABak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkTgMx1cre1Cgn0Baxtm1SjkBak1tm1ThsnTgMx1cre1CgnBaxtm2Sjk
• increased anti-double stranded DNA antibody level_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004762I129P2OlaHsd129S1Sv129X1SvJC57BL6CBABak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkTgMx1cre1Cgn0Baxtm1SjkBak1tm1ThsnTgMx1cre1CgnBaxtm2Sjk
• increased IgM level_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002494I129P2OlaHsd129S1Sv129X1SvJBak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkCd19tm1creCgnCd19Cd19Baxtm2SjkCd19tm1creCgnBaxtm1SjkBak1tm1Thsn
• increased immunoglobulin level_Bcl2l11<tm1Sjk>/Bcl2l11<tm1Sjk>
  http://metadb.riken.jp/0002461I129X1SvJBcl2l11tm1SjkBcl2l11tm1SjkBcl2l11tm1Sjk
• increased leukocyte cell number_Bak1<tm1Thsn>/Bak1<tm1Thsn>,Bax<tm1Sjk>/Bax<tm2Sjk>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000218I129P2OlaHsd129S1Sv129X1SvJC57BL6CBABak1tm1ThsnBak1tm1ThsnBaxtm1SjkBaxtm2SjkTgMx1cre1Cgn0Baxtm1SjkBak1tm1ThsnTgMx1cre1CgnBaxtm2Sjk