Luke J. Engelking, et.al., Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins., The Journal of clinical investigation, 2005, 115

http://rdf.ncbi.nlm.nih.gov/pubmed/16100574

Luke J. Engelking, et.al., Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins., The Journal of clinical investigation, 2005, 115

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Insig2<tm1Mbjg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3603525
• Insig1<tm1.1Mbjg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3607577
• Insig1<tm1Mbjg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3603523

class

http://purl.org/net/cito/citesAsAuthority

• Insig2<tm1Mbjg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3603525
• Insig1<tm1.1Mbjg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3607577
• Insig1<tm1Mbjg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3603523

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased fatty acid level_Insig1<tm1Mbjg>/Insig1<tm1Mbjg>,Insig2<tm1Mbjg>/Insig2<tm1Mbjg>,Tg(Mx1-cre)29-4Her/0
  http://metadb.riken.jp/0005281I129S6SvEvTacC57BL6JC57BL6NCrlSJLInsig1tm1MbjgInsig1tm1MbjgInsig2tm1MbjgInsig2tm1MbjgTgMx1cre294Her0TgMx1cre294HerInsig1tm1MbjgInsig2tm1Mbjg
• abnormal lipid homeostasis_Insig1<tm1Mbjg>/Insig1<tm1Mbjg>,Insig2<tm1Mbjg>/Insig2<tm1Mbjg>,Tg(Mx1-cre)29-4Her/0
  http://metadb.riken.jp/0002118I129S6SvEvTacC57BL6JC57BL6NCrlSJLInsig1tm1MbjgInsig1tm1MbjgInsig2tm1MbjgInsig2tm1MbjgTgMx1cre294Her0TgMx1cre294HerInsig1tm1MbjgInsig2tm1Mbjg
• increased circulating cholesterol level_Insig1<tm1Mbjg>/Insig1<tm1Mbjg>,Insig2<tm1Mbjg>/Insig2<tm1Mbjg>,Tg(Mx1-cre)29-4Her/0
  http://metadb.riken.jp/0005178I129S6SvEvTacC57BL6JC57BL6NCrlSJLInsig1tm1MbjgInsig1tm1MbjgInsig2tm1MbjgInsig2tm1MbjgTgMx1cre294Her0TgMx1cre294HerInsig1tm1MbjgInsig2tm1Mbjg
• abnormal cholesterol homeostasis_Insig1<tm1Mbjg>/Insig1<tm1Mbjg>,Insig2<tm1Mbjg>/Insig2<tm1Mbjg>,Tg(Mx1-cre)29-4Her/0
  http://metadb.riken.jp/0005278I129S6SvEvTacC57BL6JC57BL6NCrlSJLInsig1tm1MbjgInsig1tm1MbjgInsig2tm1MbjgInsig2tm1MbjgTgMx1cre294Her0TgMx1cre294HerInsig1tm1MbjgInsig2tm1Mbjg
• abnormal hepatobiliary system physiology_Insig1<tm1Mbjg>/Insig1<tm1Mbjg>,Insig2<tm1Mbjg>/Insig2<tm1Mbjg>,Tg(Mx1-cre)29-4Her/0
  http://metadb.riken.jp/0002139I129S6SvEvTacC57BL6JC57BL6NCrlSJLInsig1tm1MbjgInsig1tm1MbjgInsig2tm1MbjgInsig2tm1MbjgTgMx1cre294Her0TgMx1cre294HerInsig1tm1MbjgInsig2tm1Mbjg
• postnatal lethality_Insig1<tm1.1Mbjg>/Insig1<tm1.1Mbjg>,Insig2<tm1Mbjg>/Insig2<+>
  http://metadb.riken.jp/0002082I129S6SvEvTacC57BL6NCrlFVBNInsig1tm11MbjgInsig1tm11MbjgInsig2tm1MbjgInsig2Insig2tm1MbjgInsig2Insig1tm11Mbjg
• increased liver cholesterol level_Insig1<tm1Mbjg>/Insig1<tm1Mbjg>,Insig2<tm1Mbjg>/Insig2<tm1Mbjg>,Tg(Mx1-cre)29-4Her/0
  http://metadb.riken.jp/0010027I129S6SvEvTacC57BL6JC57BL6NCrlSJLInsig1tm1MbjgInsig1tm1MbjgInsig2tm1MbjgInsig2tm1MbjgTgMx1cre294Her0TgMx1cre294HerInsig1tm1MbjgInsig2tm1Mbjg
• pale liver_Insig1<tm1Mbjg>/Insig1<tm1Mbjg>,Insig2<tm1Mbjg>/Insig2<tm1Mbjg>,Tg(Mx1-cre)29-4Her/0
  http://metadb.riken.jp/0000603I129S6SvEvTacC57BL6JC57BL6NCrlSJLInsig1tm1MbjgInsig1tm1MbjgInsig2tm1MbjgInsig2tm1MbjgTgMx1cre294Her0TgMx1cre294HerInsig1tm1MbjgInsig2tm1Mbjg
• postnatal lethality_Insig1<tm1.1Mbjg>/Insig1<tm1.1Mbjg>,Insig2<tm1Mbjg>/Insig2<tm1Mbjg>
  http://metadb.riken.jp/0002082I129S6SvEvTacC57BL6NCrlFVBNInsig1tm11MbjgInsig1tm11MbjgInsig2tm1MbjgInsig2tm1MbjgInsig2tm1MbjgInsig1tm11Mbjg
• decreased circulating triglyceride level_Insig1<tm1Mbjg>/Insig1<tm1Mbjg>,Insig2<tm1Mbjg>/Insig2<tm1Mbjg>,Tg(Mx1-cre)29-4Her/0
  http://metadb.riken.jp/0002644I129S6SvEvTacC57BL6JC57BL6NCrlSJLInsig1tm1MbjgInsig1tm1MbjgInsig2tm1MbjgInsig2tm1MbjgTgMx1cre294Her0TgMx1cre294HerInsig1tm1MbjgInsig2tm1Mbjg
• abnormal liver morphology_Insig1<tm1Mbjg>/Insig1<tm1Mbjg>,Insig2<tm1Mbjg>/Insig2<tm1Mbjg>,Tg(Mx1-cre)29-4Her/0
  http://metadb.riken.jp/0000598I129S6SvEvTacC57BL6JC57BL6NCrlSJLInsig1tm1MbjgInsig1tm1MbjgInsig2tm1MbjgInsig2tm1MbjgTgMx1cre294Her0TgMx1cre294HerInsig1tm1MbjgInsig2tm1Mbjg
• increased liver triglyceride level_Insig1<tm1Mbjg>/Insig1<tm1Mbjg>,Insig2<tm1Mbjg>/Insig2<tm1Mbjg>,Tg(Mx1-cre)29-4Her/0
  http://metadb.riken.jp/0009355I129S6SvEvTacC57BL6JC57BL6NCrlSJLInsig1tm1MbjgInsig1tm1MbjgInsig2tm1MbjgInsig2tm1MbjgTgMx1cre294Her0TgMx1cre294HerInsig1tm1MbjgInsig2tm1Mbjg

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD43655
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD43655