William M. Keyes, et.al., p63 deficiency activates a program of cellular senescence and leads to accelerated aging., Genes & development, 2005, 19

http://rdf.ncbi.nlm.nih.gov/pubmed/16107615

William M. Keyes, et.al., p63 deficiency activates a program of cellular senescence and leads to accelerated aging., Genes & development, 2005, 19

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased susceptibility to infection_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0002406I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• alopecia_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0000414I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• decreased cell proliferation_Trp63<tm2Brd>/Trp63<tm2Brd>
  http://metadb.riken.jp/0000352I129S7SvEvBrdTrp63tm2BrdTrp63tm2BrdTrp63tm2Brd
• early cellular replicative senescence_Trp63<tm2Brd>/Trp63<tm2Brd>
  http://metadb.riken.jp/0008008I129S7SvEvBrdTrp63tm2BrdTrp63tm2BrdTrp63tm2Brd
• rectal prolapse_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0000493I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• skin lesions_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0001212I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• abnormal tongue epithelium morphology_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0000764I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• premature death_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0002083I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• abnormal limb morphology_Trp63<tm2Brd>/Trp63<tm2Brd>
  http://metadb.riken.jp/0002109I129S7SvEvBrdTrp63tm2BrdTrp63tm2BrdTrp63tm2Brd
• distended abdomen_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0001270I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• weight loss_Tg(KRT5-cre/PGR)1Der/0,Trp63<tm2Brd>/Trp63<tm3.1Brd>
  http://metadb.riken.jp/0001263I129S7SvEvBrdFVBICRTgKRT5crePGR1Der0Trp63tm2BrdTrp63tm31BrdTrp63tm31BrdTrp63tm2BrdTgKRT5crePGR1Der
• early cellular replicative senescence_Trp63<tm3.1Brd>/Trp63<tm3.1Brd>
  http://metadb.riken.jp/0008008I129S7SvEvBrdTrp63tm31BrdTrp63tm31BrdTrp63tm31Brd
• alopecia_Tg(KRT5-cre/PGR)1Der/0,Trp63<tm2Brd>/Trp63<tm3.1Brd>
  http://metadb.riken.jp/0000414I129S7SvEvBrdFVBICRTgKRT5crePGR1Der0Trp63tm2BrdTrp63tm31BrdTrp63tm31BrdTrp63tm2BrdTgKRT5crePGR1Der
• abnormal limb morphology_Tg(KRT5-cre/PGR)1Der/0,Trp63<tm2Brd>/Trp63<tm3.1Brd>
  http://metadb.riken.jp/0002109I129S7SvEvBrdFVBICRTgKRT5crePGR1Der0Trp63tm2BrdTrp63tm31BrdTrp63tm31BrdTrp63tm2BrdTgKRT5crePGR1Der
• abnormal skin morphology_Trp63<tm2Brd>/Trp63<tm2Brd>
  http://metadb.riken.jp/0002060I129S7SvEvBrdTrp63tm2BrdTrp63tm2BrdTrp63tm2Brd
• abnormal craniofacial morphology_Tg(KRT5-cre/PGR)1Der/0,Trp63<tm2Brd>/Trp63<tm3.1Brd>
  http://metadb.riken.jp/0000428I129S7SvEvBrdFVBICRTgKRT5crePGR1Der0Trp63tm2BrdTrp63tm31BrdTrp63tm31BrdTrp63tm2BrdTgKRT5crePGR1Der
• acanthosis_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0001874I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• enlarged lymph nodes_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0000702I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• abnormal epidermal layer morphology_Tg(KRT5-cre/PGR)1Der/0,Trp63<tm2Brd>/Trp63<tm3.1Brd>
  http://metadb.riken.jp/0001216I129S7SvEvBrdFVBICRTgKRT5crePGR1Der0Trp63tm2BrdTrp63tm31BrdTrp63tm31BrdTrp63tm2BrdTgKRT5crePGR1Der
• uterine cervix inflammation_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0009228I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• kyphosis_Tg(KRT5-cre/PGR)1Der/0,Trp63<tm2Brd>/Trp63<tm3.1Brd>
  http://metadb.riken.jp/0000160I129S7SvEvBrdFVBICRTgKRT5crePGR1Der0Trp63tm2BrdTrp63tm31BrdTrp63tm31BrdTrp63tm2BrdTgKRT5crePGR1Der
• decreased cell proliferation_Trp63<tm3.1Brd>/Trp63<tm3.1Brd>
  http://metadb.riken.jp/0000352I129S7SvEvBrdTrp63tm31BrdTrp63tm31BrdTrp63tm31Brd
• abnormal uterine cervix epithelium morphology_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0001137I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• spontaneous skin ulceration_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0001209I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• abnormal epidermal layer morphology_Trp63<tm2Brd>/Trp63<tm2Brd>
  http://metadb.riken.jp/0001216I129S7SvEvBrdTrp63tm2BrdTrp63tm2BrdTrp63tm2Brd
• hemorrhage_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0001914I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• abnormal rectum morphology_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0000492I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• abnormal skin morphology_Tg(KRT5-cre/PGR)1Der/0,Trp63<tm2Brd>/Trp63<tm3.1Brd>
  http://metadb.riken.jp/0002060I129S7SvEvBrdFVBICRTgKRT5crePGR1Der0Trp63tm2BrdTrp63tm31BrdTrp63tm31BrdTrp63tm2BrdTgKRT5crePGR1Der
• circling_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0001394I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• premature aging_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0003786I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• abnormal corneal epithelium morphology_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0006000I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• abnormal craniofacial morphology_Trp63<tm2Brd>/Trp63<tm2Brd>
  http://metadb.riken.jp/0000428I129S7SvEvBrdTrp63tm2BrdTrp63tm2BrdTrp63tm2Brd
• kidney inflammation_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0001859I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• weakness_Trp63<tm2Brd>/Trp63<+>
  http://metadb.riken.jp/0000746I129S7SvEvBrdTrp63tm2BrdTrp63Trp63Trp63tm2Brd
• early cellular replicative senescence_Tg(KRT5-cre/PGR)1Der/0,Trp63<tm2Brd>/Trp63<tm3.1Brd>
  http://metadb.riken.jp/0008008I129S7SvEvBrdFVBICRTgKRT5crePGR1Der0Trp63tm2BrdTrp63tm31BrdTrp63tm31BrdTrp63tm2BrdTgKRT5crePGR1Der