Kiyomi. Mizugishi, et.al., Essential role for sphingosine kinases in neural and vascular development., Molecular and cellular biology, 2005, 25

http://rdf.ncbi.nlm.nih.gov/pubmed/16314531

Kiyomi. Mizugishi, et.al., Essential role for sphingosine kinases in neural and vascular development., Molecular and cellular biology, 2005, 25

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Sphk2<tm1Rlp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3611080

class

http://purl.org/net/cito/citesAsAuthority

• Sphk2<tm1Rlp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3611080

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hemorrhage_S1pr1<tm1Rlp>/S1pr1<tm1Rlp>
  http://metadb.riken.jp/0001914I129S6SvEvTacS1pr1tm1RlpS1pr1tm1RlpS1pr1tm1Rlp
• abnormal diencephalon morphology_S1pr1<tm1Rlp>/S1pr1<tm1Rlp>
  http://metadb.riken.jp/0000830I129S6SvEvTacS1pr1tm1RlpS1pr1tm1RlpS1pr1tm1Rlp
• increased hindbrain apoptosis_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0012261I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• embryonic lethality during organogenesis, complete penetrance_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0011098I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• spinal hemorrhage_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0006054I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• abnormal telencephalon morphology_S1pr1<tm1Rlp>/S1pr1<tm1Rlp>
  http://metadb.riken.jp/0000787I129S6SvEvTacS1pr1tm1RlpS1pr1tm1RlpS1pr1tm1Rlp
• abnormal vascular smooth muscle morphology_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0005592I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• abnormal embryonic neuroepithelium morphology_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0004261I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• increased midbrain apoptosis_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0012503I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• abnormal vascular endothelial cell morphology_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0006055I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• exencephaly_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0000914I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• abnormal dorsal aorta morphology_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0004787I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• hemopericardium_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0005244I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• intracranial hemorrhage_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0001915I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• abnormal forebrain morphology_S1pr1<tm1Rlp>/S1pr1<tm1Rlp>
  http://metadb.riken.jp/0000783I129S6SvEvTacS1pr1tm1RlpS1pr1tm1RlpS1pr1tm1Rlp
• decreased embryonic neuroepithelium thickness_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0012703I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• hemorrhage_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0001914I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• incomplete rostral neuropore closure_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0000928I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• no abnormal phenotype detected_Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0002169I129S6SvEvTacC57BL6Sphk2tm1RlpSphk2tm1RlpSphk2tm1Rlp
• abnormal blood vessel morphology_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0001614I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• increased embryonic neuroepithelium apoptosis_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0012701I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• dilated brain ventricles_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0012676I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp
• intraventricular hemorrhage_Sphk1<tm1Rlp>/Sphk1<tm1Rlp>,Sphk2<tm1Rlp>/Sphk2<tm1Rlp>
  http://metadb.riken.jp/0001917I129S6SvEvTacC57BL6Sphk1tm1RlpSphk1tm1RlpSphk2tm1RlpSphk2tm1RlpSphk2tm1RlpSphk1tm1Rlp