Jason D. Grier, et.al., Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4., Molecular and cellular biology, 2006, 26

http://rdf.ncbi.nlm.nih.gov/pubmed/16354690

Jason D. Grier, et.al., Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4., Molecular and cellular biology, 2006, 26

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Mdm4<tm2Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3612473
• Mdm4<tm2.1Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3612474

class

http://purl.org/net/cito/citesAsAuthority

• Mdm4<tm2Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3612473
• Mdm4<tm2.1Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3612474

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• thin myocardium_Mdm2<tm1Glo>/Mdm2<tm2.1Glo>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002652I129S7SvEvBrdFVBNMdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds0Mdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds
• abnormal heart morphology_Mdm2<tm1Glo>/Mdm2<tm2.1Glo>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0000266I129S7SvEvBrdFVBNMdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds0Mdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds
• abnormal blood circulation_Mdm2<tm1Glo>/Mdm2<tm2.1Glo>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002128I129S7SvEvBrdFVBNMdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds0Mdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds
• increased cardiomyocyte apoptosis_Mdm2<tm1Glo>/Mdm2<tm2.1Glo>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003222I129S7SvEvBrdFVBNMdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds0Mdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds
• premature death_Mdm4<tm2Glo>/Mdm4<tm2.1Glo>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002083I129S4SvJaeSorC57BL6JFVBNMdm4tm2GloMdm4tm21GloTgMyh6cre2182Mds0TgMyh6cre2182MdsMdm4tm21GloMdm4tm2Glo
• embryonic lethality during organogenesis, complete penetrance_Mdm2<tm1Glo>/Mdm2<tm2.1Glo>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0011098I129S7SvEvBrdFVBNMdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds0Mdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds
• no abnormal phenotype detected_Mdm4<tm2.1Glo>/Mdm4<tm2.1Glo>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002169I129S2SvPas129S4SvJaeSorC57BL6JMdm4tm21GloMdm4tm21GloTrp53tm1TyjTrp53tm1TyjTrp53tm1TyjMdm4tm21Glo
• prenatal lethality, complete penetrance_Mdm4<tm2.1Glo>/Mdm4<tm2.1Glo>
  http://metadb.riken.jp/0011091I129S4SvJaeSorC57BL6JMdm4tm21GloMdm4tm21GloMdm4tm21Glo
• decreased embryo size_Mdm2<tm1Glo>/Mdm2<tm2.1Glo>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001698I129S7SvEvBrdFVBNMdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds0Mdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds
• hemorrhage_Mdm2<tm1Glo>/Mdm2<tm2.1Glo>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001914I129S7SvEvBrdFVBNMdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds0Mdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds
• abnormal heart ventricle morphology_Mdm2<tm1Glo>/Mdm2<tm2.1Glo>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005294I129S7SvEvBrdFVBNMdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds0Mdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds
• abnormal cardiovascular system physiology_Mdm2<tm1Glo>/Mdm2<tm2.1Glo>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001544I129S7SvEvBrdFVBNMdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds0Mdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds
• small heart_Mdm2<tm1Glo>/Mdm2<tm2.1Glo>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002188I129S7SvEvBrdFVBNMdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds0Mdm2tm1GloMdm2tm21GloTgMyh6cre2182Mds