Cyril. Berthet, et.al., Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation., Developmental cell, 2006, 10

http://rdf.ncbi.nlm.nih.gov/pubmed/16678773

Cyril. Berthet, et.al., Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation., Developmental cell, 2006, 10

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal erythrocyte morphology_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0002447I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• enlarged heart atrium_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0008725I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• ventricular septal defect_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0010402I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• abnormal eye morphology_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0002092I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• abnormal myocardial fiber morphology_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0000278I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• small heart_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0002188I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• lethality throughout fetal growth and development, incomplete penetrance_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0011109I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• abnormal cardiac output_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0001627I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• thin ventricular wall_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0000280I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• pallor_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0003717I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• decreased cell proliferation_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>,Cdkn1b<tm1Ako>/Cdkn1b<tm1Ako>
  http://metadb.riken.jp/0000352I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdkn1btm1AkoCdkn1btm1AkoCdk2tm1KaldCdkn1btm1AkoCdk4tm1Kiyo
• edema_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0001785I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• abnormal hematopoietic stem cell morphology_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0004808I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• lethality throughout fetal growth and development, complete penetrance_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>,Cdkn1b<tm1Ako>/Cdkn1b<tm1Ako>
  http://metadb.riken.jp/0011099I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdkn1btm1AkoCdkn1btm1AkoCdk2tm1KaldCdkn1btm1AkoCdk4tm1Kiyo
• decreased cell proliferation_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0000352I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• abnormal liver morphology_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0000598I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• hemorrhage_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0001914I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• abnormal fetal cardiomyocyte proliferation_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0003567I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• decreased embryo size_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0001698I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• abnormal heart valve morphology_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0000285I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald
• abnormal cell cycle_Cdk2<tm1Kald>/Cdk2<tm1Kald>,Cdk4<tm1Kiyo>/Cdk4<tm1Kiyo>
  http://metadb.riken.jp/0003077I129S1SvC57BL6Cdk2tm1KaldCdk2tm1KaldCdk4tm1KiyoCdk4tm1KiyoCdk4tm1KiyoCdk2tm1Kald