Gregory C. Ippolito, et.al., Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production., The Journal of experimental medicine, 2006, 203

http://rdf.ncbi.nlm.nih.gov/pubmed/16754718

http://rdf.ncbi.nlm.nih.gov/pubmed/16754718

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Igh<tm2Hws>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3757670
• Igh<tm2.1Hws>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3757674

class

http://purl.org/net/cito/citesAsAuthority

• Igh<tm2Hws>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3757670
• Igh<tm2.1Hws>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3757674

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased B cell number_Igh<tm2.1Hws>/Igh<tm2.1Hws>
  http://metadb.riken.jp/0005017IBALBcC57BL6NCrlDBA2NCrlIghtm21HwsIghtm21HwsIghtm21Hws
• decreased transitional stage B cell number_Igh<tm2.1Hws>/Igh<tm2.1Hws>
  http://metadb.riken.jp/0008190IBALBcC57BL6NCrlDBA2NCrlIghtm21HwsIghtm21HwsIghtm21Hws
• decreased pre-B cell number_Igh<tm2.1Hws>/Igh<tm2.1Hws>
  http://metadb.riken.jp/0008209IBALBcC57BL6NCrlDBA2NCrlIghtm21HwsIghtm21HwsIghtm21Hws
• increased marginal zone B cell number_Igh<tm2.1Hws>/Igh<tm2.1Hws>
  http://metadb.riken.jp/0008181IBALBcC57BL6NCrlDBA2NCrlIghtm21HwsIghtm21HwsIghtm21Hws
• decreased B-1a cell number_Igh<tm2.1Hws>/Igh<tm2.1Hws>
  http://metadb.riken.jp/0008168IBALBcC57BL6NCrlDBA2NCrlIghtm21HwsIghtm21HwsIghtm21Hws
• decreased IgM level_Igh<tm2.1Hws>/Igh<tm2.1Hws>
  http://metadb.riken.jp/0001806IBALBcC57BL6NCrlDBA2NCrlIghtm21HwsIghtm21HwsIghtm21Hws
• decreased follicular B cell number_Igh<tm2.1Hws>/Igh<tm2.1Hws>
  http://metadb.riken.jp/0008174IBALBcC57BL6NCrlDBA2NCrlIghtm21HwsIghtm21HwsIghtm21Hws
• abnormal humoral immune response_Igh<tm2.1Hws>/Igh<tm2.1Hws>
  http://metadb.riken.jp/0001800IBALBcC57BL6NCrlDBA2NCrlIghtm21HwsIghtm21HwsIghtm21Hws
• decreased IgG level_Igh<tm2.1Hws>/Igh<tm2.1Hws>
  http://metadb.riken.jp/0001805IBALBcC57BL6NCrlDBA2NCrlIghtm21HwsIghtm21HwsIghtm21Hws
• increased early pro-B cell number_Igh<tm2.1Hws>/Igh<tm2.1Hws>
  http://metadb.riken.jp/0003133IBALBcC57BL6NCrlDBA2NCrlIghtm21HwsIghtm21HwsIghtm21Hws
• decreased B-1b cell number_Igh<tm2.1Hws>/Igh<tm2.1Hws>
  http://metadb.riken.jp/0008170IBALBcC57BL6NCrlDBA2NCrlIghtm21HwsIghtm21HwsIghtm21Hws