Fraz A. Ismat, et.al., The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice., The Journal of clinical investigation, 2006, 116

http://rdf.ncbi.nlm.nih.gov/pubmed/16906226

Fraz A. Ismat, et.al., The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice., The Journal of clinical investigation, 2006, 116

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1Fia>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3689410
• Gt(ROSA)26Sor<tm1.1Fia>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3689411

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal somatic sensory system morphology_Gt(ROSA)26Sor<tm1Fia>/Gt(ROSA)26Sor<tm1Fia>,Hprt<tm1(CMV-cre)Brd>/Hprt<+>,Nf1<tm1Fcr>/Nf1<tm1Fcr>
  http://metadb.riken.jp/0000959I129SSvEv129SSvEvBrdGtROSA26Sortm1FiaGtROSA26Sortm1FiaHprttm1CMVcreBrdHprtNf1tm1FcrNf1tm1FcrHprtGtROSA26Sortm1FiaHprttm1CMVcreBrdNf1tm1Fcr
• abnormal somatic sensory system morphology_Gt(ROSA)26Sor<tm1Fia>/Gt(ROSA)26Sor<+>,Hprt<tm1(CMV-cre)Brd>/Hprt<+>,Nf1<tm1Fcr>/Nf1<tm1Fcr>
  http://metadb.riken.jp/0000959I129SSvEv129SSvEvBrdGtROSA26Sortm1FiaGtROSA26SorHprttm1CMVcreBrdHprtNf1tm1FcrNf1tm1FcrGtROSA26Sortm1FiaHprttm1CMVcreBrdNf1tm1FcrGtROSA26SorHprt
• abnormal spleen morphology_Gt(ROSA)26Sor<tm1Fia>/Gt(ROSA)26Sor<+>,Nf1<tm1Fcr>/Nf1<tm1Par>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0000689I129SSvEv129S1Sv129X1SvJC57BL6SJLGtROSA26Sortm1FiaGtROSA26SorNf1tm1FcrNf1tm1ParTgTekcre1Ywa0GtROSA26SorTgTekcre1YwaGtROSA26Sortm1FiaNf1tm1FcrNf1tm1Par
• no abnormal phenotype detected_Gt(ROSA)26Sor<tm1.1Fia>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002169I129SvC57BL6GtROSA26Sortm11FiaGtROSA26SorGtROSA26SorGtROSA26Sortm11Fia
• abnormal sympathetic ganglion morphology_Gt(ROSA)26Sor<tm1Fia>/Gt(ROSA)26Sor<+>,Hprt<tm1(CMV-cre)Brd>/Hprt<+>,Nf1<tm1Fcr>/Nf1<tm1Fcr>
  http://metadb.riken.jp/0001008I129SSvEv129SSvEvBrdGtROSA26Sortm1FiaGtROSA26SorHprttm1CMVcreBrdHprtNf1tm1FcrNf1tm1FcrGtROSA26Sortm1FiaHprttm1CMVcreBrdNf1tm1FcrGtROSA26SorHprt
• abnormal spleen morphology_Nf1<tm1Fcr>/Nf1<tm1Par>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0000689I129SSvEv129S1Sv129X1SvJC57BL6SJLNf1tm1FcrNf1tm1ParTgTekcre1Ywa0TgTekcre1YwaNf1tm1ParNf1tm1Fcr
• prenatal lethality, incomplete penetrance_Gt(ROSA)26Sor<tm1Fia>/Gt(ROSA)26Sor<+>,Hprt<tm1(CMV-cre)Brd>/Hprt<+>,Nf1<tm1Fcr>/Nf1<tm1Fcr>
  http://metadb.riken.jp/0011101I129SSvEv129SSvEvBrdGtROSA26Sortm1FiaGtROSA26SorHprttm1CMVcreBrdHprtNf1tm1FcrNf1tm1FcrGtROSA26Sortm1FiaHprttm1CMVcreBrdNf1tm1FcrGtROSA26SorHprt
• abnormal enzyme/coenzyme activity_Nf1<tm1Fcr>/Nf1<tm1Fcr>
  http://metadb.riken.jp/0005584I129SSvEvNf1tm1FcrNf1tm1FcrNf1tm1Fcr
• spleen fibrosis_Nf1<tm1Fcr>/Nf1<tm1Par>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0011746I129SSvEv129S1Sv129X1SvJC57BL6SJLNf1tm1FcrNf1tm1ParTgTekcre1Ywa0TgTekcre1YwaNf1tm1ParNf1tm1Fcr
• adrenal medulla hyperplasia_Gt(ROSA)26Sor<tm1Fia>/Gt(ROSA)26Sor<+>,Hprt<tm1(CMV-cre)Brd>/Hprt<+>,Nf1<tm1Fcr>/Nf1<tm1Fcr>
  http://metadb.riken.jp/0008301I129SSvEv129SSvEvBrdGtROSA26Sortm1FiaGtROSA26SorHprttm1CMVcreBrdHprtNf1tm1FcrNf1tm1FcrGtROSA26Sortm1FiaHprttm1CMVcreBrdNf1tm1FcrGtROSA26SorHprt
• embryonic lethality during organogenesis, complete penetrance_Nf1<tm1Fcr>/Nf1<tm1Fcr>
  http://metadb.riken.jp/0011098I129SSvEvNf1tm1FcrNf1tm1FcrNf1tm1Fcr
• abnormal enzyme/coenzyme level_Gt(ROSA)26Sor<tm1Fia>/Gt(ROSA)26Sor<+>,Hprt<tm1(CMV-cre)Brd>/Hprt<+>,Nf1<tm1Fcr>/Nf1<tm1Fcr>
  http://metadb.riken.jp/0005319I129SSvEv129SSvEvBrdGtROSA26Sortm1FiaGtROSA26SorHprttm1CMVcreBrdHprtNf1tm1FcrNf1tm1FcrGtROSA26Sortm1FiaHprttm1CMVcreBrdNf1tm1FcrGtROSA26SorHprt
• abnormal somatic sensory system morphology_Nf1<tm1Fcr>/Nf1<tm1Par>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0000959I129SSvEv129S1Sv129X1SvJNf1tm1FcrNf1tm1ParPax3tm1creJoePax3Pax3tm1creJoeNf1tm1FcrPax3Nf1tm1Par
• enlarged spleen_Nf1<tm1Fcr>/Nf1<tm1Par>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0000691I129SSvEv129S1Sv129X1SvJC57BL6SJLNf1tm1FcrNf1tm1ParTgTekcre1Ywa0TgTekcre1YwaNf1tm1ParNf1tm1Fcr
• abnormal dorsal root ganglion morphology_Gt(ROSA)26Sor<tm1Fia>/Gt(ROSA)26Sor<+>,Hprt<tm1(CMV-cre)Brd>/Hprt<+>,Nf1<tm1Fcr>/Nf1<tm1Fcr>
  http://metadb.riken.jp/0000961I129SSvEv129SSvEvBrdGtROSA26Sortm1FiaGtROSA26SorHprttm1CMVcreBrdHprtNf1tm1FcrNf1tm1FcrGtROSA26Sortm1FiaHprttm1CMVcreBrdNf1tm1FcrGtROSA26SorHprt
• neonatal lethality, complete penetrance_Nf1<tm1Fcr>/Nf1<tm1Par>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0011087I129SSvEv129S1Sv129X1SvJNf1tm1FcrNf1tm1ParPax3tm1creJoePax3Pax3tm1creJoeNf1tm1FcrPax3Nf1tm1Par
• prenatal lethality, complete penetrance_Gt(ROSA)26Sor<tm1Fia>/Gt(ROSA)26Sor<+>,Nf1<tm1Fcr>/Nf1<tm1Par>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0011091I129SSvEv129S1Sv129X1SvJC57BL6SJLGtROSA26Sortm1FiaGtROSA26SorNf1tm1FcrNf1tm1ParTgTekcre1Ywa0GtROSA26SorTgTekcre1YwaGtROSA26Sortm1FiaNf1tm1FcrNf1tm1Par
• adrenal medulla hyperplasia_Nf1<tm1Fcr>/Nf1<tm1Par>,Pax3<tm1(cre)Joe>/Pax3<+>
  http://metadb.riken.jp/0008301I129SSvEv129S1Sv129X1SvJNf1tm1FcrNf1tm1ParPax3tm1creJoePax3Pax3tm1creJoeNf1tm1FcrPax3Nf1tm1Par
• abnormal dorsal root ganglion morphology_Gt(ROSA)26Sor<tm1Fia>/Gt(ROSA)26Sor<+>,Nf1<tm1Fcr>/Nf1<tm1Par>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0000961I129SSvEv129S1Sv129X1SvJC57BL6SJLGtROSA26Sortm1FiaGtROSA26SorNf1tm1FcrNf1tm1ParTgTekcre1Ywa0GtROSA26SorTgTekcre1YwaGtROSA26Sortm1FiaNf1tm1FcrNf1tm1Par
• absent spleen germinal center_Nf1<tm1Fcr>/Nf1<tm1Par>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0008474I129SSvEv129S1Sv129X1SvJC57BL6SJLNf1tm1FcrNf1tm1ParTgTekcre1Ywa0TgTekcre1YwaNf1tm1ParNf1tm1Fcr

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1Fia>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3689410
• Gt(ROSA)26Sor<tm1.1Fia>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3689411