Jr-Wen. Shui, et.al., Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling., Molecular and cellular biology, 2007, 27

http://rdf.ncbi.nlm.nih.gov/pubmed/17060460

Jr-Wen. Shui, et.al., Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling., Molecular and cellular biology, 2007, 27

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ppp4c<tm1Tht>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3697685
• Ppp4c<tm2Tht>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3699355

class

http://purl.org/net/cito/citesAsAuthority

• Ppp4c<tm1Tht>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3697685
• Ppp4c<tm2Tht>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3699355

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal positive T cell selection_Ppp4c<tm1Tht>/Ppp4c<tm1Tht>,Tg(Lck-cre)548Jxm/0,Tg(TcraTcrb)425Cbn/0
  http://metadb.riken.jp/0004919IBALBcC57BL6CBAPpp4ctm1ThtPpp4ctm1ThtTgLckcre548Jxm0TgTcraTcrb425Cbn0Ppp4ctm1ThtTgLckcre548JxmTgTcraTcrb425Cbn
• abnormal T cell activation_Ppp4c<tm1Tht>/Ppp4c<tm1Tht>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0001828IC57BL6CBAPpp4ctm1ThtPpp4ctm1ThtTgLckcre548Jxm0Ppp4ctm1ThtTgLckcre548Jxm
• abnormal positive T cell selection_Ppp4c<tm1Tht>/Ppp4c<tm1Tht>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0004919IC57BL6CBAPpp4ctm1ThtPpp4ctm1ThtTgLckcre548Jxm0Ppp4ctm1ThtTgLckcre548Jxm
• abnormal T cell differentiation_Ppp4c<tm1Tht>/Ppp4c<tm1Tht>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0002145IC57BL6CBAPpp4ctm1ThtPpp4ctm1ThtTgLckcre548Jxm0Ppp4ctm1ThtTgLckcre548Jxm
• decreased double-positive T cell number_Ppp4c<tm1Tht>/Ppp4c<tm1Tht>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0005092IC57BL6CBAPpp4ctm1ThtPpp4ctm1ThtTgLckcre548Jxm0Ppp4ctm1ThtTgLckcre548Jxm
• decreased single-positive T cell number_Ppp4c<tm1Tht>/Ppp4c<tm1Tht>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0008083IC57BL6CBAPpp4ctm1ThtPpp4ctm1ThtTgLckcre548Jxm0Ppp4ctm1ThtTgLckcre548Jxm
• decreased single-positive T cell number_Ppp4c<tm1Tht>/Ppp4c<tm1Tht>,Tg(Lck-cre)548Jxm/0,Tg(TcraTcrb)425Cbn/0
  http://metadb.riken.jp/0008083IBALBcC57BL6CBAPpp4ctm1ThtPpp4ctm1ThtTgLckcre548Jxm0TgTcraTcrb425Cbn0Ppp4ctm1ThtTgLckcre548JxmTgTcraTcrb425Cbn
• increased double-negative T cell number_Ppp4c<tm1Tht>/Ppp4c<tm1Tht>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0005090IC57BL6CBAPpp4ctm1ThtPpp4ctm1ThtTgLckcre548Jxm0Ppp4ctm1ThtTgLckcre548Jxm
• decreased CD8-positive, alpha-beta T cell number_Ppp4c<tm1Tht>/Ppp4c<tm1Tht>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0008079IC57BL6CBAPpp4ctm1ThtPpp4ctm1ThtTgLckcre548Jxm0Ppp4ctm1ThtTgLckcre548Jxm
• decreased double-positive T cell number_Ppp4c<tm1Tht>/Ppp4c<tm1Tht>,Tg(Lck-cre)548Jxm/0,Tg(TcraTcrb)425Cbn/0
  http://metadb.riken.jp/0005092IBALBcC57BL6CBAPpp4ctm1ThtPpp4ctm1ThtTgLckcre548Jxm0TgTcraTcrb425Cbn0Ppp4ctm1ThtTgLckcre548JxmTgTcraTcrb425Cbn
• decreased CD4-positive, alpha beta T cell number_Ppp4c<tm1Tht>/Ppp4c<tm1Tht>,Tg(Lck-cre)548Jxm/0
  http://metadb.riken.jp/0008075IC57BL6CBAPpp4ctm1ThtPpp4ctm1ThtTgLckcre548Jxm0Ppp4ctm1ThtTgLckcre548Jxm
• embryonic lethality during organogenesis, complete penetrance_Ppp4c<tm2Tht>/Ppp4c<tm2Tht>
  http://metadb.riken.jp/0011098NSPpp4ctm2ThtPpp4ctm2ThtPpp4ctm2Tht