Yasumasa. Yoshiyama, et.al., Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model., Neuron, 2007, 53

http://rdf.ncbi.nlm.nih.gov/pubmed/17270732

Yasumasa. Yoshiyama, et.al., Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model., Neuron, 2007, 53

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-MAPT*P301S)PS19Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:3768407

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal spinal cord white matter morphology_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0008027IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• dilated brain ventricles_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0012676IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• decreased paired-pulse facilitation_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0002920IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• limb grasping_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0001513IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• neurodegeneration_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0002229IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• decreased hippocampus volume_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0020083IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• loss of hippocampal neurons_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0003240IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• abnormal amygdala morphology_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0000818IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• tau protein deposits_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0004250IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• abnormal CNS synaptic transmission_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0002206IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• hunched posture_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0001505IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• progressive muscle weakness_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0000748IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• abnormal sexual interaction_Tg(Prnp-MAPT*P301S)PS19Vle/Tg(Prnp-MAPT*P301S)PS19Vle
  http://metadb.riken.jp/0002566IC3HC57BL6TgPrnpMAPTP301SPS19VleTgPrnpMAPTP301SPS19VleTgPrnpMAPTP301SPS19Vle
• astrocytosis_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0003354IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• paralysis_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0000753IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• hippocampal neuron degeneration_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0000811IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• premature death_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0002083IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• weakness_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0000746IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• neurofibrillary tangles_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0003214IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• hippocampus atrophy_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0030003IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• reduced long term potentiation_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0001473IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• abnormal entorhinal cortex morphology_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0006300IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• abnormal hippocampus pyramidal cell morphology_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0009940IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• abnormal hippocampal mossy fiber morphology_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0002761IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• abnormal cerebral cortex morphology_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0000788IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• abnormal excitatory postsynaptic potential_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0002912IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• abnormal dentate gyrus morphology_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0000812IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• dystrophic muscle_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0000752IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle
• brain atrophy_Tg(Prnp-MAPT*P301S)PS19Vle/0
  http://metadb.riken.jp/0012506IC3HC57BL6TgPrnpMAPTP301SPS19Vle0TgPrnpMAPTP301SPS19Vle

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-MAPT*P301S)PS19Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:3768407