Florence A. Scholl, et.al., Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia., Developmental cell, 2007, 12

http://rdf.ncbi.nlm.nih.gov/pubmed/17419998

Florence A. Scholl, et.al., Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia., Developmental cell, 2007, 12

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• eyelids open at birth_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0001302I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• skin hypoplasia_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre/ERT2)1Ipc/?
  http://metadb.riken.jp/0001215I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14creERT21IpcTgKRT14creERT21IpcMap2k1tm1ChrnMap2k2tm1Chrn
• skin hypoplasia_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0001215I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• impaired skin barrier function_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0002796I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• neonatal lethality, incomplete penetrance_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0011088I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• abnormal tongue epithelium morphology_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0000764I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• abnormal outer ear morphology_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0002177I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• increased keratinocyte apoptosis_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0009580I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• abnormal hair follicle morphology_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0000377I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• shiny skin_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0001196I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• skin hypoplasia_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-RAF1/ESR1)1Pkha/?
  http://metadb.riken.jp/0001215I129SvC57BL6C57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14RAF1ESR11PkhaMap2k1tm1ChrnTgKRT14RAF1ESR11PkhaMap2k2tm1Chrn
• abnormal vibrissa follicle morphology_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0010234I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• decreased body weight_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0001262I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• translucent skin_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0001201I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• decreased body size_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre)1Efu/?
  http://metadb.riken.jp/0001265I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14cre1EfuTgKRT14cre1EfuMap2k2tm1ChrnMap2k1tm1Chrn
• abnormal tongue epithelium morphology_Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>,Tg(KRT14-cre/ERT2)1Ipc/?
  http://metadb.riken.jp/0000764I129SvC57BL6JSJLMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnTgKRT14creERT21IpcTgKRT14creERT21IpcMap2k1tm1ChrnMap2k2tm1Chrn