Changchuin. Mao, et.al., Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition., Journal of immunology (Baltimore, Md. : 1950), 2007, 178

http://rdf.ncbi.nlm.nih.gov/pubmed/17442925

Changchuin. Mao, et.al., Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition., Journal of immunology (Baltimore, Md. : 1950), 2007, 178

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Akt1<tm1Pnt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3794787
• Akt1<Gt1Pnt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3794786

class

http://purl.org/net/cito/citesAsAuthority

• Akt1<tm1Pnt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3794787
• Akt1<Gt1Pnt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3794786

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased double-positive T cell number_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005092I129P2OlaHsdAkt1tm1PntAkt1tm1PntAkt2tm11MbbAkt2tm11MbbTgLckcre1Cwi0Akt2tm11MbbAkt1tm1PntTgLckcre1Cwi
• increased double-positive T cell number_Rag2<tm1Fwa>/Rag2<tm1Fwa>,Tg(Lck-Akt1*)M-1Pnt/0
  http://metadb.riken.jp/0005091I129SSvEvC3HHeC57BL6Rag2tm1FwaRag2tm1FwaTgLckAkt1M1Pnt0TgLckAkt1M1PntRag2tm1Fwa
• absent CD4-positive, alpha beta T cells_Rag2<tm1Fwa>/Rag2<tm1Fwa>,Tg(Lck-Akt1*)M-1Pnt/0
  http://metadb.riken.jp/0003790I129SSvEvC3HHeC57BL6Rag2tm1FwaRag2tm1FwaTgLckAkt1M1Pnt0TgLckAkt1M1PntRag2tm1Fwa
• increased double-positive T cell number_Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(Lck-Akt1*E40K)E-3Pnt/0
  http://metadb.riken.jp/0005091I129S7SvEvBrdC3HHeC57BL6Rag1tm1MomRag1tm1MomTgLckAkt1E40KE3Pnt0Rag1tm1MomTgLckAkt1E40KE3Pnt
• no abnormal phenotype detected_Akt1<Gt1Pnt>/Akt1<Gt1Pnt>
  http://metadb.riken.jp/0002169NSAkt1Gt1PntAkt1Gt1PntAkt1Gt1Pnt
• arrested T cell differentiation_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Akt3<tm1Mbb>/Akt3<tm1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001825I129P2OlaHsdAkt1tm1PntAkt1tm1PntAkt2tm11MbbAkt2tm11MbbAkt3tm1MbbAkt3tm1MbbTgLckcre1Cwi0TgLckcre1CwiAkt3tm1MbbAkt1tm1PntAkt2tm11Mbb
• increased single-positive T cell number_Tg(Lck-Akt1*)M-1Pnt/0
  http://metadb.riken.jp/0008082IC3HHeC57BL6TgLckAkt1M1Pnt0TgLckAkt1M1Pnt
• increased double-negative T cell number_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Akt3<tm1Mbb>/Akt3<tm1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005090I129P2OlaHsdAkt1tm1PntAkt1tm1PntAkt2tm11MbbAkt2tm11MbbAkt3tm1MbbAkt3tm1MbbTgLckcre1Cwi0TgLckcre1CwiAkt3tm1MbbAkt1tm1PntAkt2tm11Mbb
• increased double-negative T cell number_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005090I129P2OlaHsdAkt1tm1PntAkt1tm1PntAkt2tm11MbbAkt2tm11MbbTgLckcre1Cwi0Akt2tm11MbbAkt1tm1PntTgLckcre1Cwi
• absent CD8-positive, alpha-beta T cells_Rag2<tm1Fwa>/Rag2<tm1Fwa>,Tg(Lck-Akt1*)M-1Pnt/0
  http://metadb.riken.jp/0000727I129SSvEvC3HHeC57BL6Rag2tm1FwaRag2tm1FwaTgLckAkt1M1Pnt0TgLckAkt1M1PntRag2tm1Fwa
• no abnormal phenotype detected_Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Akt3<tm1Mbb>/Akt3<tm1Mbb>
  http://metadb.riken.jp/0002169I129P2OlaHsdAkt2tm11MbbAkt2tm11MbbAkt3tm1MbbAkt3tm1MbbAkt3tm1MbbAkt2tm11Mbb
• decreased double-positive T cell number_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Akt3<tm1Mbb>/Akt3<tm1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005092I129P2OlaHsdAkt1tm1PntAkt1tm1PntAkt2tm11MbbAkt2tm11MbbAkt3tm1MbbAkt3tm1MbbTgLckcre1Cwi0TgLckcre1CwiAkt3tm1MbbAkt1tm1PntAkt2tm11Mbb
• increased thymocyte number_Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(Lck-Akt1*E40K)E-3Pnt/0
  http://metadb.riken.jp/0000714I129S7SvEvBrdC3HHeC57BL6Rag1tm1MomRag1tm1MomTgLckAkt1E40KE3Pnt0Rag1tm1MomTgLckAkt1E40KE3Pnt
• arrested T cell differentiation_Tcra<tm1Mom>/Tcra<tm1Mom>,Tg(Lck-Akt1*E40K)E-3Pnt/0
  http://metadb.riken.jp/0001825I129S2SvPasC3HHeC57BL6Tcratm1MomTcratm1MomTgLckAkt1E40KE3Pnt0Tcratm1MomTgLckAkt1E40KE3Pnt
• arrested T cell differentiation_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001825I129P2OlaHsdAkt1tm1PntAkt1tm1PntAkt2tm11MbbAkt2tm11MbbTgLckcre1Cwi0Akt2tm11MbbAkt1tm1PntTgLckcre1Cwi
• thymus hypoplasia_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001823I129P2OlaHsdAkt1tm1PntAkt1tm1PntAkt2tm11MbbAkt2tm11MbbTgLckcre1Cwi0Akt2tm11MbbAkt1tm1PntTgLckcre1Cwi
• increased T cell apoptosis_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0006413I129P2OlaHsdAkt1tm1PntAkt1tm1PntAkt2tm11MbbAkt2tm11MbbTgLckcre1Cwi0Akt2tm11MbbAkt1tm1PntTgLckcre1Cwi
• decreased double-positive T cell number_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt3<tm1Mbb>/Akt3<tm1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005092NSAkt1tm1PntAkt1tm1PntAkt3tm1MbbAkt3tm1MbbTgLckcre1Cwi0Akt1tm1PntAkt3tm1MbbTgLckcre1Cwi
• increased T cell apoptosis_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Akt3<tm1Mbb>/Akt3<tm1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0006413I129P2OlaHsdAkt1tm1PntAkt1tm1PntAkt2tm11MbbAkt2tm11MbbAkt3tm1MbbAkt3tm1MbbTgLckcre1Cwi0TgLckcre1CwiAkt3tm1MbbAkt1tm1PntAkt2tm11Mbb
• increased double-negative T cell number_Tg(Lck-Akt1*)M-1Pnt/0
  http://metadb.riken.jp/0005090IC3HHeC57BL6TgLckAkt1M1Pnt0TgLckAkt1M1Pnt
• no abnormal phenotype detected_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0002169NSAkt1tm1PntAkt1tm1PntTgLckcre1Cwi0TgLckcre1CwiAkt1tm1Pnt
• thymus hypoplasia_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Akt3<tm1Mbb>/Akt3<tm1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001823I129P2OlaHsdAkt1tm1PntAkt1tm1PntAkt2tm11MbbAkt2tm11MbbAkt3tm1MbbAkt3tm1MbbTgLckcre1Cwi0TgLckcre1CwiAkt3tm1MbbAkt1tm1PntAkt2tm11Mbb
• thymus hypoplasia_Akt1<tm1Pnt>/Akt1<tm1Pnt>,Akt3<tm1Mbb>/Akt3<tm1Mbb>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001823NSAkt1tm1PntAkt1tm1PntAkt3tm1MbbAkt3tm1MbbTgLckcre1Cwi0Akt1tm1PntAkt3tm1MbbTgLckcre1Cwi