Xi. Huang, et.al., Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly., Human molecular genetics, 2007, 16

http://rdf.ncbi.nlm.nih.gov/pubmed/17468181

Xi. Huang, et.al., Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly., Human molecular genetics, 2007, 16

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased midbrain size_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0012091I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• perinatal lethality, complete penetrance_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0011089I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• absent olfactory bulb_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0003451I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• abnormal lateral ganglionic eminence morphology_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0004277I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• abnormal neurocranium morphology_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000074I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• abnormal corpus callosum morphology_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000780I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• perinatal lethality_Shh<tm1Chg>/Shh<tm2Chg>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0002081I129S1Sv129X1SvJC57BL6CBAShhtm1ChgShhtm2ChgTgSox2cre1Amc0TgSox2cre1AmcShhtm1ChgShhtm2Chg
• holoprosencephaly_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0005157I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• abnormal hippocampus development_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000808I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• cleft secondary palate_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0009890I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• enlarged brain ventricles_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0011380I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• palatal shelves fail to meet at midline_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0009888I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• abnormal maxillary shelf morphology_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0004538I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• abnormal telencephalon development_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000934I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• increased forebrain size_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0012139I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• abnormal choroid plexus morphology_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000820I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• abnormal telencephalon morphology_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000787I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• abnormal medial ganglionic eminence morphology_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0004276I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg
• abnormal embryonic/fetal subventricular zone morphology_Shh<tm2Chg>/Shh<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0004274I129S1Sv129X1SvJC57BL6CBAShhtm2ChgShhTgSox2cre1Amc0ShhTgSox2cre1AmcShhtm2Chg