Shannon E. Mullican, et.al., Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia., Nature medicine, 2007, 13

http://rdf.ncbi.nlm.nih.gov/pubmed/17515897

Shannon E. Mullican, et.al., Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia., Nature medicine, 2007, 13

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased granulocyte number_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0000322I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• postnatal lethality, complete penetrance_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0011085I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• enlarged spleen_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0000691I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• increased hematopoietic stem cell number_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0004809I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• abnormal myelopoiesis_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0001601I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• increased leukocyte cell number_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0000218I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• hunched posture_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0001505I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• abnormal bone marrow cell number_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0000172I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• increased eosinophil cell number_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0005011I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• abnormal thymus morphology_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0000703I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• abnormal spleen morphology_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0000689I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• increased leukemia incidence_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0002026I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• enlarged lymph nodes_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0000702I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• ruffled hair_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0000420I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• anemia_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0001577I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• abnormal common myeloid progenitor cell morphology_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0006410I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• abnormal leukopoiesis_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0005460I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• increased neutrophil cell number_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0000219I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• enlarged liver_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0000599I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• decreased body size_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0001265I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi
• decreased lymphocyte cell number_Nr4a1<tm1Jmi>/Nr4a1<tm1Jmi>,Nr4a3<tm1Omc>/Nr4a3<tm1Omc>
  http://metadb.riken.jp/0005016I129SSvEv129S2SvPasC57BL6Nr4a1tm1JmiNr4a1tm1JmiNr4a3tm1OmcNr4a3tm1OmcNr4a3tm1OmcNr4a1tm1Jmi