Tamara. Terzian, et.al., Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development., Molecular and cellular biology, 2007, 27

http://rdf.ncbi.nlm.nih.gov/pubmed/17526734

Tamara. Terzian, et.al., Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development., Molecular and cellular biology, 2007, 27

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cerebellar granule layer morphology_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0000886I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• abnormal Purkinje cell morphology_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0000877I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• decreased body weight_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0001262I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• thymus hypoplasia_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0001823I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• decreased bone marrow cell number_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0000333I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• increased B cell derived lymphoma incidence_Mdm4<tm1Glo>/Mdm4<+>,Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0002023I129S6SvEvTacC57BLC57BL6SJLMdm4tm1GloMdm4TgIghMyc22Bri0TgIghMyc22BriMdm4Mdm4tm1Glo
• cleft palate_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0000111I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• abnormal cerebellum external granule cell layer morphology_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0000872I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• pancytopenia_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0005152I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• decreased renal glomerulus number_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0004505I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• decreased fetal size_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0004200I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• exencephaly_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0000914I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• decreased embryo size_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0001698I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• decreased leukocyte cell number_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0000221I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• prenatal lethality, incomplete penetrance_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0011101I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• increased mortality induced by ionizing radiation_Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0003992I129S6SvEvTacC57BL6Mdm4tm1GloMdm4Mdm4tm1GloMdm4
• pallor_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0003717I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• kinked tail_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0000585I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• decreased erythrocyte cell number_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0002875I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• abnormal definitive hematopoiesis_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0002123I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• abnormal cell physiology_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0005621I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• anemia_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0001577I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• postnatal lethality, complete penetrance_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0011085I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• abnormal cell physiology_Mdm2<tm1Glo>/Mdm2<+>
  http://metadb.riken.jp/0005621I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm2Mdm2tm1Glo
• abnormal cell physiology_Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0005621I129S6SvEvTacC57BL6Mdm4tm1GloMdm4Mdm4tm1GloMdm4
• decreased hemoglobin content_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0002874I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• increased mortality induced by ionizing radiation_Mdm2<tm1Glo>/Mdm2<+>
  http://metadb.riken.jp/0003992I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm2Mdm2tm1Glo
• thymus atrophy_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0003644I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• increased embryonic tissue cell apoptosis_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0013504I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• cerebellum hypoplasia_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0000851I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• spleen atrophy_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0003643I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• thrombocytopenia_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0003179I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo
• spleen hypoplasia_Mdm2<tm1Glo>/Mdm2<+>,Mdm4<tm1Glo>/Mdm4<+>
  http://metadb.riken.jp/0000694I129S6SvEvTac129S7SvEvBrdC57BL6Mdm2tm1GloMdm2Mdm4tm1GloMdm4Mdm2Mdm4tm1GloMdm4Mdm2tm1Glo