Sung O. Park, et.al., ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2., Blood, 2008, 111

http://rdf.ncbi.nlm.nih.gov/pubmed/17911384

Sung O. Park, et.al., ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2., Blood, 2008, 111

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Acvrl1<tm2.1Spo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4398901
• Acvrl1<tm2Spo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4398904
• Tg(Acvrl1-cre)L1Spo
  http://metadb.riken.jp/db/mgi_rdf/MGI:4398903
• Acvrl1<tm2.2Spo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4398902

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal dorsal aorta morphology_Acvrl1<tm2Spo>/Acvrl1<tm2Spo>,Tg(Acvrl1-cre)L1Spo/0
  http://metadb.riken.jp/0004787I129129S4SvJaeC57BL6FVBNAcvrl1tm2SpoAcvrl1tm2SpoTgAcvrl1creL1Spo0TgAcvrl1creL1SpoAcvrl1tm2Spo
• embryonic lethality during organogenesis, complete penetrance_Acvrl1<tm2.2Spo>/Acvrl1<tm2.2Spo>
  http://metadb.riken.jp/0011098I129C57BL6FVBNAcvrl1tm22SpoAcvrl1tm22SpoAcvrl1tm22Spo
• dilated vasculature_Acvrl1<tm2Spo>/Acvrl1<tm2Spo>,Tg(Acvrl1-cre)L1Spo/0
  http://metadb.riken.jp/0004938I129129S4SvJaeC57BL6FVBNAcvrl1tm2SpoAcvrl1tm2SpoTgAcvrl1creL1Spo0TgAcvrl1creL1SpoAcvrl1tm2Spo
• no abnormal phenotype detected_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Acvrl1-cre)L1Spo/0
  http://metadb.riken.jp/0002169I129S6SvEvTacFVBNTgfbr2tm12HlmTgfbr2tm12HlmTgAcvrl1creL1Spo0TgAcvrl1creL1SpoTgfbr2tm12Hlm
• abnormal vitelline vasculature morphology_Acvrl1<tm2Spo>/Acvrl1<tm2Spo>,Tg(Acvrl1-cre)L1Spo/0
  http://metadb.riken.jp/0003229I129129S4SvJaeC57BL6FVBNAcvrl1tm2SpoAcvrl1tm2SpoTgAcvrl1creL1Spo0TgAcvrl1creL1SpoAcvrl1tm2Spo
• no abnormal phenotype detected_Acvrl1<tm2.1Spo>/Acvrl1<tm2.1Spo>
  http://metadb.riken.jp/0002169I129C57BL6FVBNAcvrl1tm21SpoAcvrl1tm21SpoAcvrl1tm21Spo
• no abnormal phenotype detected_Acvrl1<tm1Spo>/Acvrl1<tm2Spo>
  http://metadb.riken.jp/0002169I129129S4SvJaeC57BL6Acvrl1tm1SpoAcvrl1tm2SpoAcvrl1tm1SpoAcvrl1tm2Spo
• lethality throughout fetal growth and development, complete penetrance_Acvrl1<tm2Spo>/Acvrl1<tm2Spo>,Tg(Acvrl1-cre)L1Spo/0
  http://metadb.riken.jp/0011099I129129S4SvJaeC57BL6FVBNAcvrl1tm2SpoAcvrl1tm2SpoTgAcvrl1creL1Spo0TgAcvrl1creL1SpoAcvrl1tm2Spo
• absent vitelline blood vessels_Acvrl1<tm2.2Spo>/Acvrl1<tm2.2Spo>
  http://metadb.riken.jp/0001719I129C57BL6FVBNAcvrl1tm22SpoAcvrl1tm22SpoAcvrl1tm22Spo
• arteriovenous malformation_Acvrl1<tm2Spo>/Acvrl1<tm2Spo>,Tg(Acvrl1-cre)L1Spo/0
  http://metadb.riken.jp/0006093I129129S4SvJaeC57BL6FVBNAcvrl1tm2SpoAcvrl1tm2SpoTgAcvrl1creL1Spo0TgAcvrl1creL1SpoAcvrl1tm2Spo
• no abnormal phenotype detected_Tgfbr1<tm1.1Karl>/Tgfbr1<tm1.1Karl>,Tg(Acvrl1-cre)L1Spo/0
  http://metadb.riken.jp/0002169I129FVBTgfbr1tm11KarlTgfbr1tm11KarlTgAcvrl1creL1Spo0TgAcvrl1creL1SpoTgfbr1tm11Karl
• hemorrhage_Acvrl1<tm2.2Spo>/Acvrl1<tm2.2Spo>
  http://metadb.riken.jp/0001914I129C57BL6FVBNAcvrl1tm22SpoAcvrl1tm22SpoAcvrl1tm22Spo
• abnormal lung vasculature morphology_Acvrl1<tm2Spo>/Acvrl1<tm2Spo>,Tg(Acvrl1-cre)L1Spo/0
  http://metadb.riken.jp/0004007I129129S4SvJaeC57BL6FVBNAcvrl1tm2SpoAcvrl1tm2SpoTgAcvrl1creL1Spo0TgAcvrl1creL1SpoAcvrl1tm2Spo
• vascular smooth muscle hypotrophy_Acvrl1<tm2Spo>/Acvrl1<tm2Spo>,Tg(Acvrl1-cre)L1Spo/0
  http://metadb.riken.jp/0002976I129129S4SvJaeC57BL6FVBNAcvrl1tm2SpoAcvrl1tm2SpoTgAcvrl1creL1Spo0TgAcvrl1creL1SpoAcvrl1tm2Spo
• embryonic growth retardation_Acvrl1<tm2.2Spo>/Acvrl1<tm2.2Spo>
  http://metadb.riken.jp/0003984I129C57BL6FVBNAcvrl1tm22SpoAcvrl1tm22SpoAcvrl1tm22Spo

class

http://purl.org/net/cito/citesAsAuthority

• Acvrl1<tm2.1Spo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4398901
• Acvrl1<tm2Spo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4398904
• Tg(Acvrl1-cre)L1Spo
  http://metadb.riken.jp/db/mgi_rdf/MGI:4398903
• Acvrl1<tm2.2Spo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4398902