Kevin M. Haigis, et.al., Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon., Nature genetics, 2008, 40

http://rdf.ncbi.nlm.nih.gov/pubmed/18372904

Kevin M. Haigis, et.al., Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon., Nature genetics, 2008, 40

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Nras<tm1Tyj>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775824

class

http://purl.org/net/cito/citesAsAuthority

• Nras<tm1Tyj>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775824

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased intestinal adenocarcinoma incidence_Apc<tm2.1Cip>/Apc<+>,Kras<tm4Tyj>/Kras<+>,Tg(Fabp1-cre)1Jig/0
  http://metadb.riken.jp/0002957I129P2OlaHsd129S4SvJaeFVBApctm21CipApcKrastm4TyjKrasTgFabp1cre1Jig0TgFabp1cre1JigApctm21CipApcKrastm4TyjKras
• decreased physiological sensitivity to xenobiotic_Nras<tm1Tyj>/Nras<+>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0008874IC57BL6DBA2Nrastm1TyjNrasTgVilcre20Syr0Nrastm1TyjNrasTgVilcre20Syr
• abnormal large intestine crypts of Lieberkuhn morphology_Kras<tm4Tyj>/Kras<+>,Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004842I129S4SvJaeKrastm4TyjKrasGtROSA26Sortm1creERT2TyjGtROSA26SorGtROSA26SorKrastm4TyjGtROSA26Sortm1creERT2TyjKras
• abnormal intestinal goblet cell morphology_Kras<tm4Tyj>/Kras<+>,Tg(Fabp1-cre)1Jig/0
  http://metadb.riken.jp/0003449I129P2OlaHsd129S4SvJaeC57BL6FVBNKrastm4TyjKrasTgFabp1cre1Jig0TgFabp1cre1JigKrastm4TyjKras
• increased intestinal adenocarcinoma incidence_Apc<tm2.1Cip>/Apc<+>,Tg(Fabp1-cre)1Jig/0
  http://metadb.riken.jp/0002957I129P2OlaHsdFVBNApctm21CipApcTgFabp1cre1Jig0ApcApctm21CipTgFabp1cre1Jig
• abnormal intestinal epithelium morphology_Kras<tm4Tyj>/Kras<+>,Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000488I129S4SvJaeKrastm4TyjKrasGtROSA26Sortm1creERT2TyjGtROSA26SorGtROSA26SorKrastm4TyjGtROSA26Sortm1creERT2TyjKras
• abnormal colon goblet cell morphology_Kras<tm4Tyj>/Kras<+>,Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0013795I129S4SvJaeKrastm4TyjKrasGtROSA26Sortm1creERT2TyjGtROSA26SorGtROSA26SorKrastm4TyjGtROSA26Sortm1creERT2TyjKras
• abnormal large intestine crypts of Lieberkuhn morphology_Kras<tm4Tyj>/Kras<+>,Tg(Fabp1-cre)1Jig/0
  http://metadb.riken.jp/0004842I129P2OlaHsd129S4SvJaeC57BL6FVBNKrastm4TyjKrasTgFabp1cre1Jig0TgFabp1cre1JigKrastm4TyjKras
• premature death_Apc<tm2.1Cip>/Apc<+>,Kras<tm4Tyj>/Kras<+>,Tg(Fabp1-cre)1Jig/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeFVBApctm21CipApcKrastm4TyjKrasTgFabp1cre1Jig0TgFabp1cre1JigApctm21CipApcKrastm4TyjKras
• abnormal intestinal epithelium morphology_Kras<tm4Tyj>/Kras<+>,Tg(Fabp1-cre)1Jig/0
  http://metadb.riken.jp/0000488I129P2OlaHsd129S4SvJaeC57BL6FVBNKrastm4TyjKrasTgFabp1cre1Jig0TgFabp1cre1JigKrastm4TyjKras