Cornelia. Hömig-Hölzel, et.al., Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis., The Journal of experimental medicine, 2008, 205

http://rdf.ncbi.nlm.nih.gov/pubmed/18490492

Cornelia. Hömig-Hölzel, et.al., Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis., The Journal of experimental medicine, 2008, 205

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5567929

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged liver_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0000599I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• abnormal immune system morphology_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0000685IBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorTgCr2cre3Cgn0GtROSA26Sortm2Lmp1CD40UzsTgCr2cre3CgnGtROSA26Sor
• enlarged spleen_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0000691I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• abnormal immune system physiology_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0001790IBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorTgCr2cre3Cgn0GtROSA26Sortm2Lmp1CD40UzsTgCr2cre3CgnGtROSA26Sor
• abnormal humoral immune response_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0001800I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• abnormal T cell activation_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0001828I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
他12件を見る
• increased B cell derived lymphoma incidence_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002023I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• abnormal B cell physiology_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002459I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• abnormal class switch recombination_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004816I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• increased spleen weight_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004952I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• increased B cell number_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005014I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• increased T cell number_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005015I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• increased B cell proliferation_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005154I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• increased follicular B cell number_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008173I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• increased marginal zone B cell number_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008181I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• abnormal B cell activation_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008217I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• abnormal spleen B cell follicle morphology_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008470I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19
• enlarged inguinal lymph nodes_Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0009623I129P2OlaHsdBALBcC57BL6GtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19tm1creCgnCd19Cd19tm1creCgnGtROSA26Sortm2Lmp1CD40UzsGtROSA26SorCd19

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2(Lmp1/CD40)Uzs>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5567929