Ikuroh. Ohsawa, et.al., Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 28

http://rdf.ncbi.nlm.nih.gov/pubmed/18550766

Ikuroh. Ohsawa, et.al., Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 28

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/db/mgi_rdf/MGI:5699091

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• muscle weakness_Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/0000747C57BL6TgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101Oht
• impaired spatial learning_Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/0012307C57BL6TgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101Oht
• increased sensitivity to induced cell death_Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/0008943C57BL6TgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101Oht
• oxidative stress_Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/0003674C57BL6TgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101Oht
• abnormal hippocampus morphology_Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/0000807C57BL6TgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101Oht
• impaired spatial learning_Apoe<tm1Unc>/Apoe<tm1Unc>,Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/0012307B6CgApoetm1UncTgEIF1AXAldh2E487K101OhtApoetm1UncApoetm1UncTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtApoetm1Unc
• hippocampus pyramidal cell degeneration_Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/0010014C57BL6TgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101Oht
• abnormal coat/hair pigmentation_Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/0002075C57BL6TgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101Oht
• astrocytosis_Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/0003354C57BL6TgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101Oht
• abnormal object recognition memory_Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/0001458C57BL6TgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101Oht
• premature death_Tg(EIF1AX-Aldh2*E487K)101Oht/Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/0002083C57BL6TgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101OhtTgEIF1AXAldh2E487K101Oht

class

http://purl.org/net/cito/citesAsAuthority

• Tg(EIF1AX-Aldh2*E487K)101Oht
  http://metadb.riken.jp/db/mgi_rdf/MGI:5699091

article

http://www.w3.org/2000/01/rdf-schema#seeAlso

• [Blank]

BRC マウスの系統

http://purl.org/net/cito/citesAsAuthority

• C57BL/6-Tg(EIF1AX-Aldh2<*>E504K)101Oht
  http://metadb.riken.jp/db/rikenbrc_mouse/RBRC09897

article

http://www.w3.org/2000/01/rdf-schema#seeAlso

• [Blank]