T. Pearson, et.al., A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function., Diabetologia, 2008, 51

http://rdf.ncbi.nlm.nih.gov/pubmed/18563383

T. Pearson, et.al., A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function., Diabetologia, 2008, 51

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• postnatal lethality, complete penetrance_Ins2<Akita>/Ins2<Akita>,Prf1<tm1Sdz>/Prf1<tm1Sdz>,Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0011085NODCgRag1tm1MomIns2AkitaPrf1tm1SdzIns2AkitaIns2AkitaPrf1tm1SdzPrf1tm1SdzRag1tm1MomRag1tm1MomIns2AkitaRag1tm1MomPrf1tm1Sdz
• abnormal pancreatic islet morphology_Ins2<Akita>/Ins2<+>,Prf1<tm1Sdz>/Prf1<tm1Sdz>,Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0005215NODCgRag1tm1MomIns2AkitaPrf1tm1SdzIns2AkitaIns2Prf1tm1SdzPrf1tm1SdzRag1tm1MomRag1tm1MomPrf1tm1SdzIns2Rag1tm1MomIns2Akita
• absent T cells_Ins2<Akita>/Ins2<+>,Prf1<tm1Sdz>/Prf1<tm1Sdz>,Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0008070NODCgRag1tm1MomIns2AkitaPrf1tm1SdzIns2AkitaIns2Prf1tm1SdzPrf1tm1SdzRag1tm1MomRag1tm1MomPrf1tm1SdzIns2Rag1tm1MomIns2Akita
• absent mature B cells_Ins2<Akita>/Ins2<+>,Prf1<tm1Sdz>/Prf1<tm1Sdz>,Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0008212NODCgRag1tm1MomIns2AkitaPrf1tm1SdzIns2AkitaIns2Prf1tm1SdzPrf1tm1SdzRag1tm1MomRag1tm1MomPrf1tm1SdzIns2Rag1tm1MomIns2Akita
• increased macrophage cell number_Ins2<Akita>/Ins2<+>,Prf1<tm1Sdz>/Prf1<tm1Sdz>,Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0005425NODCgRag1tm1MomIns2AkitaPrf1tm1SdzIns2AkitaIns2Prf1tm1SdzPrf1tm1SdzRag1tm1MomRag1tm1MomPrf1tm1SdzIns2Rag1tm1MomIns2Akita
• increased monocyte cell number_Ins2<Akita>/Ins2<+>,Prf1<tm1Sdz>/Prf1<tm1Sdz>,Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0000220NODCgRag1tm1MomIns2AkitaPrf1tm1SdzIns2AkitaIns2Prf1tm1SdzPrf1tm1SdzRag1tm1MomRag1tm1MomPrf1tm1SdzIns2Rag1tm1MomIns2Akita
• increased granulocyte number_Ins2<Akita>/Ins2<+>,Prf1<tm1Sdz>/Prf1<tm1Sdz>,Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0000322NODCgRag1tm1MomIns2AkitaPrf1tm1SdzIns2AkitaIns2Prf1tm1SdzPrf1tm1SdzRag1tm1MomRag1tm1MomPrf1tm1SdzIns2Rag1tm1MomIns2Akita
• increased erythrocyte cell number_Ins2<Akita>/Ins2<+>,Prf1<tm1Sdz>/Prf1<tm1Sdz>,Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0003131NODCgRag1tm1MomIns2AkitaPrf1tm1SdzIns2AkitaIns2Prf1tm1SdzPrf1tm1SdzRag1tm1MomRag1tm1MomPrf1tm1SdzIns2Rag1tm1MomIns2Akita
• abnormal glucose homeostasis_Ins2<Akita>/Ins2<+>,Prf1<tm1Sdz>/Prf1<tm1Sdz>,Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0002078NODCgRag1tm1MomIns2AkitaPrf1tm1SdzIns2AkitaIns2Prf1tm1SdzPrf1tm1SdzRag1tm1MomRag1tm1MomPrf1tm1SdzIns2Rag1tm1MomIns2Akita
• abnormal glucose homeostasis_Il2rg<tm1Wjl>/Il2rg<tm1Wjl>,Prkdc<scid>/Prkdc<scid>
  http://metadb.riken.jp/0002078NODCgPrkdcscidIl2rgtm1WjlSzIl2rgtm1WjlIl2rgtm1WjlPrkdcscidPrkdcscidPrkdcscidIl2rgtm1Wjl
• hyperglycemia_Il2rg<tm1Wjl>/Il2rg<tm1Wjl>,Prkdc<scid>/Prkdc<scid>
  http://metadb.riken.jp/0001559NODCgPrkdcscidIl2rgtm1WjlSzIl2rgtm1WjlIl2rgtm1WjlPrkdcscidPrkdcscidPrkdcscidIl2rgtm1Wjl
• hyperglycemia_Ins2<Akita>/Ins2<+>,Prf1<tm1Sdz>/Prf1<tm1Sdz>,Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0001559NODCgRag1tm1MomIns2AkitaPrf1tm1SdzIns2AkitaIns2Prf1tm1SdzPrf1tm1SdzRag1tm1MomRag1tm1MomPrf1tm1SdzIns2Rag1tm1MomIns2Akita