Nicholas. Warr, et.al., Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation., Human molecular genetics, 2008, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/18617531

Nicholas. Warr, et.al., Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation., Human molecular genetics, 2008, 17

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• proboscis_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0006290C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• abnormal eye distance/ position_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0001299C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• cyclopia_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0005163C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• abnormal prechordal plate morphology_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0004387C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• abnormal forebrain morphology_Shh<tm1Chg>/Shh<tm1Chg>,Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0000783I129S1Sv129X1SvJBALBcAnNCrlC3HHeHShhtm1ChgShhtm1ChgZic2KuZic2KuZic2KuShhtm1Chg
• abnormal notochord morphology_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0002825C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• abnormal forebrain development_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0003232C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• curly tail_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0003051C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• abnormal primitive node morphology_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0004066C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• holoprosencephaly_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0005157C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• increased ectoderm apoptosis_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0003895C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• decreased embryo size_Shh<tm1Chg>/Shh<tm1Chg>,Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0001698I129S1Sv129X1SvJBALBcAnNCrlC3HHeHShhtm1ChgShhtm1ChgZic2KuZic2KuZic2KuShhtm1Chg
• failure of initiation of embryo turning_Shh<tm1Chg>/Shh<tm1Chg>,Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0004180I129S1Sv129X1SvJBALBcAnNCrlC3HHeHShhtm1ChgShhtm1ChgZic2KuZic2KuZic2KuShhtm1Chg
• exencephaly_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0000914C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• ocular hypotelorism_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0006197C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku
• no abnormal phenotype detected_Shh<+>/Shh<tm1Chg>,Zic2<Ku>/Zic2<+>
  http://metadb.riken.jp/0002169I129S1Sv129X1SvJBALBcAnNCrlC3HHeHShhShhtm1ChgZic2KuZic2Zic2ShhZic2KuShhtm1Chg
• abnormal heart morphology_Shh<tm1Chg>/Shh<tm1Chg>,Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0000266I129S1Sv129X1SvJBALBcAnNCrlC3HHeHShhtm1ChgShhtm1ChgZic2KuZic2KuZic2KuShhtm1Chg
• spina bifida_Zic2<Ku>/Zic2<Ku>
  http://metadb.riken.jp/0003054C3CAnNCrlZic2KuZic2KuZic2KuZic2Ku