Lei. Tian, et.al., ADAM10 is essential for proteolytic activation of Notch during thymocyte development., International immunology, 2008, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/18635581

Lei. Tian, et.al., ADAM10 is essential for proteolytic activation of Notch during thymocyte development., International immunology, 2008, 20

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Adam10<tm1.1Zhu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809599
• Adam10<tm1Zhu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809598

class

http://purl.org/net/cito/citesAsAuthority

• Adam10<tm1.1Zhu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809599
• Adam10<tm1Zhu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809598

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased double-positive T cell number_Adam10<tm1Zhu>/Adam10<tm1.1Zhu>,Tg(Lck-cre)#Zhu/0
  http://metadb.riken.jp/0005092I129S6SvEvTacC57BL6SJLSJLJAdam10tm1ZhuAdam10tm11ZhuTgLckcreZhu0Adam10tm1ZhuAdam10tm11ZhuTgLckcreZhu
• embryonic lethality during organogenesis, complete penetrance_Adam10<tm1.1Zhu>/Adam10<tm1.1Zhu>
  http://metadb.riken.jp/0011098I129S6SvEvTacC57BL6SJLAdam10tm11ZhuAdam10tm11ZhuAdam10tm11Zhu
• abnormal T cell differentiation_Adam10<tm1Zhu>/Adam10<tm1.1Zhu>,Tg(Lck-cre)#Zhu/0
  http://metadb.riken.jp/0002145I129S6SvEvTacC57BL6SJLSJLJAdam10tm1ZhuAdam10tm11ZhuTgLckcreZhu0Adam10tm1ZhuAdam10tm11ZhuTgLckcreZhu
• thymus hypoplasia_Adam10<tm1Zhu>/Adam10<tm1Zhu>,Tg(Lck-cre)#Zhu/0
  http://metadb.riken.jp/0001823I129S6SvEvTacC57BL6SJLJAdam10tm1ZhuAdam10tm1ZhuTgLckcreZhu0TgLckcreZhuAdam10tm1Zhu
• abnormal T cell differentiation_Adam10<tm1Zhu>/Adam10<tm1Zhu>,Tg(Lck-cre)#Zhu/0
  http://metadb.riken.jp/0002145I129S6SvEvTacC57BL6SJLJAdam10tm1ZhuAdam10tm1ZhuTgLckcreZhu0TgLckcreZhuAdam10tm1Zhu
• thymus hypoplasia_Adam10<tm1Zhu>/Adam10<tm1.1Zhu>,Tg(Lck-cre)#Zhu/0
  http://metadb.riken.jp/0001823I129S6SvEvTacC57BL6SJLSJLJAdam10tm1ZhuAdam10tm11ZhuTgLckcreZhu0Adam10tm1ZhuAdam10tm11ZhuTgLckcreZhu
• decreased CD4-positive, alpha beta T cell number_Adam10<tm1Zhu>/Adam10<tm1.1Zhu>,Tg(Lck-cre)#Zhu/0
  http://metadb.riken.jp/0008075I129S6SvEvTacC57BL6SJLSJLJAdam10tm1ZhuAdam10tm11ZhuTgLckcreZhu0Adam10tm1ZhuAdam10tm11ZhuTgLckcreZhu
• decreased CD4-positive, alpha beta T cell number_Adam10<tm1Zhu>/Adam10<tm1Zhu>,Tg(Lck-cre)#Zhu/0
  http://metadb.riken.jp/0008075I129S6SvEvTacC57BL6SJLJAdam10tm1ZhuAdam10tm1ZhuTgLckcreZhu0TgLckcreZhuAdam10tm1Zhu
• decreased double-positive T cell number_Adam10<tm1Zhu>/Adam10<tm1Zhu>,Tg(Lck-cre)#Zhu/0
  http://metadb.riken.jp/0005092I129S6SvEvTacC57BL6SJLJAdam10tm1ZhuAdam10tm1ZhuTgLckcreZhu0TgLckcreZhuAdam10tm1Zhu