Yoshiteru. Sasaki, et.al., NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105

http://rdf.ncbi.nlm.nih.gov/pubmed/18663224

Yoshiteru. Sasaki, et.al., NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809723
• Gt(ROSA)26Sor<tm5(Map3k14)Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809722

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased mature B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm5(Map3k14)Rsky>/Gt(ROSA)26Sor<tm5(Map3k14)Rsky>,Tnfrsf13c<tm1Mass>/Tnfrsf13c<tm1Mass>
  http://metadb.riken.jp/0008211I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm5Map3k14RskyGtROSA26Sortm5Map3k14RskyTnfrsf13ctm1MassTnfrsf13ctm1MassCd19tm1creCgnTnfrsf13ctm1MassGtROSA26Sortm5Map3k14RskyCd19
• abnormal spleen B cell follicle morphology_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>/Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>
  http://metadb.riken.jp/0008470I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm6Map3k14RskyGtROSA26Sortm6Map3k14RskyCd19tm1creCgnGtROSA26Sortm6Map3k14RskyCd19
• increased lymphocyte cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>/Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>,Tnfrsf13c<tm1Mass>/Tnfrsf13c<tm1Mass>
  http://metadb.riken.jp/0005013I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm6Map3k14RskyGtROSA26Sortm6Map3k14RskyTnfrsf13ctm1MassTnfrsf13ctm1MassCd19GtROSA26Sortm6Map3k14RskyCd19tm1creCgnTnfrsf13ctm1Mass
• abnormal Peyer's patch morphology_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>/Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>
  http://metadb.riken.jp/0000696I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm6Map3k14RskyGtROSA26Sortm6Map3k14RskyCd19tm1creCgnGtROSA26Sortm6Map3k14RskyCd19
• enlarged lymph nodes_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm5(Map3k14)Rsky>/Gt(ROSA)26Sor<tm5(Map3k14)Rsky>
  http://metadb.riken.jp/0000702I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm5Map3k14RskyGtROSA26Sortm5Map3k14RskyCd19GtROSA26Sortm5Map3k14RskyCd19tm1creCgn
• decreased lymphocyte cell number_Tnfrsf13c<tm1Mass>/Tnfrsf13c<tm1Mass>
  http://metadb.riken.jp/0005016IC57BL6Tnfrsf13ctm1MassTnfrsf13ctm1MassTnfrsf13ctm1Mass
• decreased B-1 B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>/Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>
  http://metadb.riken.jp/0004978I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm6Map3k14RskyGtROSA26Sortm6Map3k14RskyCd19tm1creCgnGtROSA26Sortm6Map3k14RskyCd19
• decreased mature B cell number_Tnfrsf13c<tm1Mass>/Tnfrsf13c<tm1Mass>
  http://metadb.riken.jp/0008211IC57BL6Tnfrsf13ctm1MassTnfrsf13ctm1MassTnfrsf13ctm1Mass
• increased mature B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>/Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>
  http://metadb.riken.jp/0008210I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm6Map3k14RskyGtROSA26Sortm6Map3k14RskyCd19tm1creCgnGtROSA26Sortm6Map3k14RskyCd19
• increased mature B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm5(Map3k14)Rsky>/Gt(ROSA)26Sor<tm5(Map3k14)Rsky>
  http://metadb.riken.jp/0008210I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm5Map3k14RskyGtROSA26Sortm5Map3k14RskyCd19GtROSA26Sortm5Map3k14RskyCd19tm1creCgn
• increased marginal zone B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm5(Map3k14)Rsky>/Gt(ROSA)26Sor<tm5(Map3k14)Rsky>
  http://metadb.riken.jp/0008181I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm5Map3k14RskyGtROSA26Sortm5Map3k14RskyCd19GtROSA26Sortm5Map3k14RskyCd19tm1creCgn
• enlarged lymph nodes_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>/Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>
  http://metadb.riken.jp/0000702I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm6Map3k14RskyGtROSA26Sortm6Map3k14RskyCd19tm1creCgnGtROSA26Sortm6Map3k14RskyCd19
• increased mature B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>/Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>,Tnfrsf13c<tm1Mass>/Tnfrsf13c<tm1Mass>
  http://metadb.riken.jp/0008210I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm6Map3k14RskyGtROSA26Sortm6Map3k14RskyTnfrsf13ctm1MassTnfrsf13ctm1MassCd19GtROSA26Sortm6Map3k14RskyCd19tm1creCgnTnfrsf13ctm1Mass
• enlarged spleen_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm5(Map3k14)Rsky>/Gt(ROSA)26Sor<tm5(Map3k14)Rsky>
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm5Map3k14RskyGtROSA26Sortm5Map3k14RskyCd19GtROSA26Sortm5Map3k14RskyCd19tm1creCgn
• decreased lymphocyte cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm5(Map3k14)Rsky>/Gt(ROSA)26Sor<tm5(Map3k14)Rsky>,Tnfrsf13c<tm1Mass>/Tnfrsf13c<tm1Mass>
  http://metadb.riken.jp/0005016I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm5Map3k14RskyGtROSA26Sortm5Map3k14RskyTnfrsf13ctm1MassTnfrsf13ctm1MassCd19tm1creCgnTnfrsf13ctm1MassGtROSA26Sortm5Map3k14RskyCd19
• enlarged spleen_Cd19<tm1(cre)Cgn>/Cd19<+>,Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>/Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6Cd19tm1creCgnCd19GtROSA26Sortm6Map3k14RskyGtROSA26Sortm6Map3k14RskyCd19tm1creCgnGtROSA26Sortm6Map3k14RskyCd19

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm6(Map3k14*)Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809723
• Gt(ROSA)26Sor<tm5(Map3k14)Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3809722