Jeffrey. Buis, et.al., Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation., Cell, 2008, 135

http://rdf.ncbi.nlm.nih.gov/pubmed/18854157

Jeffrey. Buis, et.al., Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation., Cell, 2008, 135

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Mre11a<tm2.2Dof>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3839940
• Mre11a<tm1Dof>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3839938
• Mre11a<tm2.1Dof>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3839939

class

http://purl.org/net/cito/citesAsAuthority

• Mre11a<tm2.2Dof>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3839940
• Mre11a<tm1Dof>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3839938
• Mre11a<tm2.1Dof>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3839939

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased cellular sensitivity to ionizing radiation_Mre11a<tm1Dof>/Mre11a<tm2.1Dof>
  http://metadb.riken.jp/0004227I129S6SvEvTacMre11atm1DofMre11atm21DofMre11atm1DofMre11atm21Dof
• increased cellular sensitivity to ionizing radiation_Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0004227I129S6SvEvTacLig4tm1FwaLig4tm1FwaLig4tm1Fwa
• chromosomal instability_Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0008866I129S6SvEvTacLig4tm1FwaLig4tm1FwaLig4tm1Fwa
• chromosomal instability_Mre11a<tm1Dof>/Mre11a<tm2.1Dof>
  http://metadb.riken.jp/0008866I129S6SvEvTacMre11atm1DofMre11atm21DofMre11atm1DofMre11atm21Dof
• induced chromosome breakage_Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0004030I129S6SvEvTacLig4tm1FwaLig4tm1FwaLig4tm1Fwa
• increased cellular sensitivity to ionizing radiation_Mre11a<tm2.1Dof>/Mre11a<tm2.2Dof>
  http://metadb.riken.jp/0004227NSMre11atm21DofMre11atm22DofMre11atm22DofMre11atm21Dof
• embryonic lethality during organogenesis, complete penetrance_Mre11a<tm1Dof>/Mre11a<tm1Dof>
  http://metadb.riken.jp/0011098I129S6SvEvTacMre11atm1DofMre11atm1DofMre11atm1Dof
• chromosomal instability_Mre11a<tm2.1Dof>/Mre11a<tm2.2Dof>
  http://metadb.riken.jp/0008866NSMre11atm21DofMre11atm22DofMre11atm22DofMre11atm21Dof
• abnormal embryo development_Mre11a<tm1Dof>/Mre11a<tm1Dof>
  http://metadb.riken.jp/0001672I129S6SvEvTacMre11atm1DofMre11atm1DofMre11atm1Dof
• abnormal DNA repair_Mre11a<tm1Dof>/Mre11a<tm2.1Dof>
  http://metadb.riken.jp/0008058I129S6SvEvTacMre11atm1DofMre11atm21DofMre11atm1DofMre11atm21Dof
• decreased cell proliferation_Mre11a<tm2.1Dof>/Mre11a<tm2.2Dof>
  http://metadb.riken.jp/0000352NSMre11atm21DofMre11atm22DofMre11atm22DofMre11atm21Dof
• embryonic growth arrest_Mre11a<tm1Dof>/Mre11a<tm1Dof>
  http://metadb.riken.jp/0001730I129S6SvEvTacMre11atm1DofMre11atm1DofMre11atm1Dof
• induced chromosome breakage_Mre11a<tm1Dof>/Mre11a<tm2.1Dof>
  http://metadb.riken.jp/0004030I129S6SvEvTacMre11atm1DofMre11atm21DofMre11atm1DofMre11atm21Dof
• abnormal heart development_Mre11a<tm1Dof>/Mre11a<tm1Dof>
  http://metadb.riken.jp/0000267I129S6SvEvTacMre11atm1DofMre11atm1DofMre11atm1Dof
• abnormal cell cycle checkpoint function_Mre11a<tm2.1Dof>/Mre11a<tm2.2Dof>
  http://metadb.riken.jp/0004045NSMre11atm21DofMre11atm22DofMre11atm22DofMre11atm21Dof
• spontaneous chromosome breakage_Mre11a<tm2.1Dof>/Mre11a<tm2.2Dof>
  http://metadb.riken.jp/0004029NSMre11atm21DofMre11atm22DofMre11atm22DofMre11atm21Dof
• decreased cell proliferation_Mre11a<tm1Dof>/Mre11a<tm2.1Dof>
  http://metadb.riken.jp/0000352I129S6SvEvTacMre11atm1DofMre11atm21DofMre11atm1DofMre11atm21Dof
• induced chromosome breakage_Mre11a<tm2.1Dof>/Mre11a<tm2.2Dof>
  http://metadb.riken.jp/0004030NSMre11atm21DofMre11atm22DofMre11atm22DofMre11atm21Dof
• abnormal DNA repair_Mre11a<tm2.1Dof>/Mre11a<tm2.2Dof>
  http://metadb.riken.jp/0008058NSMre11atm21DofMre11atm22DofMre11atm22DofMre11atm21Dof