Vijay K. Yadav, et.al., Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum., Cell, 2008, 135

http://rdf.ncbi.nlm.nih.gov/pubmed/19041748

Vijay K. Yadav, et.al., Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum., Cell, 2008, 135

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Lrp5<tm2Kry>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837394
• Lrp5<tm3(Lrp5*)Kry>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837395
• Htr2b<tm1Kry>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837400
• Tph1<tm1Kry>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837399

class

http://purl.org/net/cito/citesAsAuthority

• Lrp5<tm2Kry>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837394
• Lrp5<tm3(Lrp5*)Kry>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837395
• Htr2b<tm1Kry>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837400
• Tph1<tm1Kry>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3837399

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased bone mass_Lrp5<tm2Kry>/Lrp5<tm2Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0004016IC57BL6DBA2Lrp5tm2KryLrp5tm2KryTgVilcre20Syr0TgVilcre20SyrLrp5tm2Kry
• increased osteoblast cell number_Htr1b<tm1Rhn>/Htr1b<+>
  http://metadb.riken.jp/0004988I129S2SvPasHtr1btm1RhnHtr1bHtr1btm1RhnHtr1b
• increased bone ossification_Htr1b<tm1Rhn>/Htr1b<tm1Rhn>
  http://metadb.riken.jp/0020039I129S2SvPasHtr1btm1RhnHtr1btm1RhnHtr1btm1Rhn
• increased bone ossification_Lrp5<tm3(Lrp5*)Kry>/Lrp5<tm3(Lrp5*)Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0020039IC57BL6DBA2Lrp5tm3Lrp5KryLrp5tm3Lrp5KryTgVilcre20Syr0Lrp5tm3Lrp5KryTgVilcre20Syr
• abnormal osteoblast physiology_Tph1<tm1Kry>/Tph1<tm1Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0005006IC57BL6DBA2Tph1tm1KryTph1tm1KryTgVilcre20Syr0TgVilcre20SyrTph1tm1Kry
• increased bone mass_Htr1b<tm1Rhn>/Htr1b<+>,Tph1<tm1Kry>/Tph1<+>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0005605I129S2SvPasC57BL6DBA2Htr1btm1RhnHtr1bTph1tm1KryTph1TgVilcre20Syr0Tph1tm1KryHtr1bHtr1btm1RhnTph1TgVilcre20Syr
• abnormal serotonin level_Lrp5<tm1Kry>/Lrp5<+>
  http://metadb.riken.jp/0005322I129S1Sv129X1SvJLrp5tm1KryLrp5Lrp5Lrp5tm1Kry
• decreased bone ossification_Lrp5<tm2Kry>/Lrp5<tm2Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0020040IC57BL6DBA2Lrp5tm2KryLrp5tm2KryTgVilcre20Syr0TgVilcre20SyrLrp5tm2Kry
• increased bone mass_Htr1b<tm1Rhn>/Htr1b<tm1Rhn>
  http://metadb.riken.jp/0005605I129S2SvPasHtr1btm1RhnHtr1btm1RhnHtr1btm1Rhn
• increased osteoblast cell number_Htr1b<tm1Rhn>/Htr1b<tm1Rhn>
  http://metadb.riken.jp/0004988I129S2SvPasHtr1btm1RhnHtr1btm1RhnHtr1btm1Rhn
• decreased bone ossification_Lrp5<tm2Kry>/Lrp5<+>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0020040IC57BL6DBA2Lrp5tm2KryLrp5TgVilcre20Syr0Lrp5TgVilcre20SyrLrp5tm2Kry
• abnormal serotonin level_Lrp5<tm3(Lrp5*)Kry>/Lrp5<tm3(Lrp5*)Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0005322IC57BL6DBA2Lrp5tm3Lrp5KryLrp5tm3Lrp5KryTgVilcre20Syr0Lrp5tm3Lrp5KryTgVilcre20Syr
• abnormal serotonin level_Tph1<tm1Kry>/Tph1<tm1Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0005322IC57BL6DBA2Tph1tm1KryTph1tm1KryTgVilcre20Syr0TgVilcre20SyrTph1tm1Kry
• decreased bone mass_Lrp5<tm1Kry>/Lrp5<tm1Kry>
  http://metadb.riken.jp/0004016I129S1Sv129X1SvJLrp5tm1KryLrp5tm1KryLrp5tm1Kry
• abnormal osteoblast physiology_Lrp5<tm2Kry>/Lrp5<tm2Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0005006IC57BL6DBA2Lrp5tm2KryLrp5tm2KryTgVilcre20Syr0TgVilcre20SyrLrp5tm2Kry
• abnormal bone ossification_Tph1<tm1Kry>/Tph1<tm1Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0008271IC57BL6DBA2Tph1tm1KryTph1tm1KryTgVilcre20Syr0TgVilcre20SyrTph1tm1Kry
• decreased bone mass_Creb1<tm3Gsc>/Creb1<+>,Lrp5<tm1Kry>/Lrp5<+>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0004016I129P2OlaHsd129S1Sv129X1SvJFVBCreb1tm3GscCreb1Lrp5tm1KryLrp5TgCol1a1cre1Kry0TgCol1a1cre1KryCreb1tm3GscCreb1Lrp5Lrp5tm1Kry
• decreased bone ossification_Creb1<tm3Gsc>/Creb1<+>,Lrp5<tm1Kry>/Lrp5<+>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0020040I129P2OlaHsd129S1Sv129X1SvJFVBCreb1tm3GscCreb1Lrp5tm1KryLrp5TgCol1a1cre1Kry0TgCol1a1cre1KryCreb1tm3GscCreb1Lrp5Lrp5tm1Kry
• increased osteoblast cell number_Tph1<tm1Kry>/Tph1<tm1Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0004988IC57BL6DBA2Tph1tm1KryTph1tm1KryTgVilcre20Syr0TgVilcre20SyrTph1tm1Kry
• increased bone mass_Lrp5<tm3(Lrp5*)Kry>/Lrp5<tm3(Lrp5*)Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0005605IC57BL6DBA2Lrp5tm3Lrp5KryLrp5tm3Lrp5KryTgVilcre20Syr0Lrp5tm3Lrp5KryTgVilcre20Syr
• increased bone mass_Tph1<tm1Kry>/Tph1<tm1Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0005605IC57BL6DBA2Tph1tm1KryTph1tm1KryTgVilcre20Syr0TgVilcre20SyrTph1tm1Kry
• decreased bone mass_Lrp5<tm2Kry>/Lrp5<+>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0004016IC57BL6DBA2Lrp5tm2KryLrp5TgVilcre20Syr0Lrp5TgVilcre20SyrLrp5tm2Kry
• increased bone mass_Htr1b<tm1Rhn>/Htr1b<+>
  http://metadb.riken.jp/0005605I129S2SvPasHtr1btm1RhnHtr1bHtr1btm1RhnHtr1b
• abnormal serotonin level_Lrp5<tm2Kry>/Lrp5<tm2Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0005322IC57BL6DBA2Lrp5tm2KryLrp5tm2KryTgVilcre20Syr0TgVilcre20SyrLrp5tm2Kry
• persistence of hyaloid vascular system_Lrp5<tm1Kry>/Lrp5<tm1Kry>
  http://metadb.riken.jp/0001289I129S1Sv129X1SvJLrp5tm1KryLrp5tm1KryLrp5tm1Kry
• decreased osteoblast cell number_Lrp5<tm2Kry>/Lrp5<tm2Kry>,Tg(Vil-cre)20Syr/0
  http://metadb.riken.jp/0004989IC57BL6DBA2Lrp5tm2KryLrp5tm2KryTgVilcre20Syr0TgVilcre20SyrLrp5tm2Kry
• abnormal osteoblast physiology_Htr1b<tm1Rhn>/Htr1b<tm1Rhn>
  http://metadb.riken.jp/0005006I129S2SvPasHtr1btm1RhnHtr1btm1RhnHtr1btm1Rhn
• abnormal serotonin level_Lrp5<tm1Kry>/Lrp5<tm1Kry>
  http://metadb.riken.jp/0005322I129S1Sv129X1SvJLrp5tm1KryLrp5tm1KryLrp5tm1Kry
• increased bone ossification_Htr1b<tm1Rhn>/Htr1b<+>
  http://metadb.riken.jp/0020039I129S2SvPasHtr1btm1RhnHtr1bHtr1btm1RhnHtr1b

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD19378
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD19378