Christina J. Sigurdson, et.al., De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106

http://rdf.ncbi.nlm.nih.gov/pubmed/19073920

Christina J. Sigurdson, et.al., De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp*S170N*N174T)1020Aag
  http://metadb.riken.jp/db/mgi_rdf/MGI:5569540

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp*S170N*N174T)1020Aag
  http://metadb.riken.jp/db/mgi_rdf/MGI:5569540

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• astrocytosis_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0003354I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• lethargy_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0005202I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• increased pruritus_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0010072I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• spongiform encephalopathy_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0002654I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• muscle degeneration_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0000749I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• weight loss_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0001263I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• abnormal sciatic nerve morphology_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0002651I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• circling_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0001394I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• abnormal corpus callosum morphology_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0000780I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• increased susceptibility to prion infection_Tg(Prnp)a20Cwe/0
  http://metadb.riken.jp/0005364NSTgPrnpa20Cwe0TgPrnpa20Cwe
• abnormal brain morphology_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0002152I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• abnormal hippocampus stratum lacunosum morphology_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0011149I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• microgliosis_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0008918I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• abnormal cingulum morphology_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0008232I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• decreased susceptibility to prion infection_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0005363I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• abnormal muscle fiber morphology_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0004087I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• paresis_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0000754I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• kyphosis_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0000160I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag
• ataxia_Prnp<tm1Cwe>/Prnp<tm1Cwe>,Tg(Prnp*S170N*N174T)1020Aag/0
  http://metadb.riken.jp/0001393I129S7SvEvBrdC57BL6Prnptm1CwePrnptm1CweTgPrnpS170NN174T1020Aag0Prnptm1CweTgPrnpS170NN174T1020Aag